Thorén T, Carlsson E, Sandmark S, Wattwil M
Department of Anaesthesia and Intensive Care, Orebro Medical Centre Hospital, Sweden.
Acta Anaesthesiol Scand. 1988 Jul;32(5):391-4. doi: 10.1111/j.1399-6576.1988.tb02752.x.
Lower oesophageal peristalsis and lower oesophageal sphincter (LOS) pressure during thoracic epidural analgesia (TEA) were studied in 20 healthy volunteers. After oesophageal manometric baseline recordings, 10 volunteers received 4 mg epidural morphine. The other ten received 0.5% bupivacaine epidurally in sufficient amounts to block the sympathetic innervation of the oesophagus. Thereafter oesophageal manometry was repeated. During epidural morphine oesophageal peristalsis, resting LOS pressure and the contraction of LOS after swallowing did not change, but the relaxation of the LOS in response to swallowing decreased significantly (P less than 0.01). Following TEA with bupivacaine, neither distal oesophageal peristalsis nor LOS pressure changed.
对20名健康志愿者进行了研究，观察其在胸段硬膜外镇痛（TEA）期间的食管下段蠕动和食管下括约肌（LOS）压力。在进行食管测压基线记录后，10名志愿者接受了4毫克硬膜外吗啡。另外10名志愿者接受了足量的0.5%布比卡因硬膜外注射，以阻断食管的交感神经支配。此后重复进行食管测压。在硬膜外注射吗啡期间，食管蠕动、静息LOS压力以及吞咽后LOS的收缩均未改变，但吞咽引起的LOS松弛显著降低（P<0.01）。在使用布比卡因进行TEA后，食管下段蠕动和LOS压力均未改变。
