Helm J F, Massey B T, Martin C J, Dodds W J, Hogan W J, Arndorfer R C
Digestive System Research Center, Medical College of Wisconsin, Milwaukee.
Gut. 1990 Mar;31(3):266-9. doi: 10.1136/gut.31.3.266.
We studied the effect of distal oesophageal acidification on lower oesophageal sphincter (LOS) pressure in normal human volunteers and in cats. The distal oesophagus was acidified by intraluminal injection of 0.1N HCl (pH 1.2). The LOS pressure was recorded by a sleeve device while pharyngeal and oesophageal pressures were monitored by nonperfused, water filled catheters. In normal human subjects, distal oesophageal acidification did not elicit a change in LOS pressure. In anaesthetised cats, injection of acid into the distal oesophagus elicited immediate LOS relaxation followed by a secondary peristaltic sequence. With propagation of the peristaltic sequence into the LOS, the LOS pressure abruptly increased 20-100 mmHg and gradually returned to the preinjection value over 15-180 s. In the one instance in which we were able to acidify the distal oesophagus without evoking secondary peristalsis, the LOS pressure did not change. Injection of saline into the distal oesophagus evoked a response in the LOS and oesophageal body that was indistinguishable from that seen with acid. We conclude that contrary to common belief, distal oesophageal acidification itself does not affect LOS pressure in man or the cat.
我们研究了食管远端酸化对正常人类志愿者和猫的食管下括约肌（LOS）压力的影响。通过向管腔内注射0.1N盐酸（pH 1.2）使食管远端酸化。使用套管装置记录LOS压力，同时通过未灌注的充水导管监测咽部和食管压力。在正常人类受试者中，食管远端酸化并未引起LOS压力的变化。在麻醉的猫中，向食管远端注射酸会立即引起LOS松弛，随后出现继发性蠕动序列。随着蠕动序列传播至LOS，LOS压力突然升高20 - 100 mmHg，并在15 - 180秒内逐渐恢复到注射前的值。在我们能够酸化食管远端而不诱发继发性蠕动的一个实例中，LOS压力没有变化。向食管远端注射生理盐水在LOS和食管体中引起的反应与注射酸时所见的反应无法区分。我们得出结论，与普遍看法相反，食管远端酸化本身并不会影响人类或猫的LOS压力。
