Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hospital Pharmacy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Int J Artif Organs. 2021 Oct;44(10):783-786. doi: 10.1177/03913988211021101. Epub 2021 Jun 18.
The advanced organ support (ADVOS) system allows to eliminate water-soluble as well as protein-bound molecules. Despite its clinical features, to date nothing is known about the elimination of clinically relevant drugs such as antiinfectives. Therefore, we report a case treated with ADVOS, continuous renal replacement therapy (CRRT), and meropenem (1 g 8-hourly) for empiric sepsis therapy monitored by meropenem drug levels. ADVOS showed more efficient elimination of meropenem compared to CRRT which has to be considered when evaluating dosing regimens.
高级器官支持（ADVOS）系统可清除水溶性和蛋白结合性分子。尽管 ADVOS 具有临床特点，但迄今为止，尚无关于其清除临床相关药物（如抗感染药物）的相关信息。因此，我们报告了 1 例使用 ADVOS、连续性肾脏替代治疗（CRRT）和美罗培南（1 g，8 小时 1 次）治疗经验性脓毒症患者的病例，通过美罗培南药物水平进行监测。与 CRRT 相比，ADVOS 显示出更有效的美罗培南清除率，在评估给药方案时应予以考虑。
