Clinic of Gastroenterology, Tsaritsa Yoanna University Hospital, Medical University of Sofia, Sofia, Bulgaria.
Department of Gastroenterology, Pulmed University Hospital, Plovdiv, Bulgaria.
Neurogastroenterol Motil. 2022 Feb;34(2):e14197. doi: 10.1111/nmo.14197. Epub 2021 Jun 18.
Quarantine with social distancing has reduced transmission of COVID-19; however, fear of the disease and these remedial measures cause anxiety and stress. It is not known whether these events have impacted the prevalence of gastrointestinal (GI) symptoms and disorders of brain-gut interaction (DGBI).
An online platform evaluated the prevalence of GI symptoms during the COVID-19 pandemic. Data collection utilized validated questionnaires and was fully anonymized. Findings were compared with identical data acquired in 2019. The association of results with stress and anxiety was analyzed.
Data were collected from 1896 subjects May - August 2019 to 980 non-identical subjects May - June 2020. GI symptoms were reported by 68.9% during the COVID-19 lockdown compared with 56.0% the previous year (p < 0.001). The prevalence of irritable bowel syndrome (26.3% vs. 20.0%; p < 0.001), functional dyspepsia (18.3% vs. 12.7%; p < 0.001), heartburn (31.7% vs. 26.2%, p = 0.002), and self-reported milk intolerance (43.5% vs. 37.8% p = 0.004) was higher during the pandemic. Many individuals reported multiple symptoms. Anxiety was associated with presence of all GI symptoms. High levels of stress impacted functional dyspepsia (p = 0.045) and abdominal pain (p = 0.013). The presence of DGBI (p < 0.001; OR 22.99), self-reported milk intolerance (p < 0.001; OR 2.50), and anxiety (p < 0.001; OR 2.18) was independently associated with increased GI symptoms during COVID-19 pandemic.
The prevalence of GI symptoms was significantly higher during the COVID-19 lockdown than under normal circumstances the previous year. This increase was attributable to increased numbers of patients with DGBI, an effect that was associated with anxiety.
社交隔离的检疫措施已经降低了 COVID-19 的传播；然而，对疾病的恐惧和这些补救措施导致了焦虑和压力。目前尚不清楚这些事件是否对胃肠道（GI）症状的流行和脑-肠相互作用障碍（DGBI）产生了影响。
一个在线平台评估了 COVID-19 大流行期间 GI 症状的流行情况。数据收集利用了经过验证的问卷，并且完全匿名。将调查结果与 2019 年获得的相同数据进行了比较。分析了结果与压力和焦虑的关系。
2019 年 5 月至 8 月期间，从 1896 名受试者和 2020 年 5 月至 6 月期间的 980 名非相同受试者收集了 GI 症状数据。与前一年（p < 0.001）相比，COVID-19 封锁期间报告有 68.9%的人出现 GI 症状，而前一年为 56.0%。肠易激综合征（26.3% vs. 20.0%；p < 0.001）、功能性消化不良（18.3% vs. 12.7%；p < 0.001）、烧心（31.7% vs. 26.2%，p = 0.002）和自我报告的牛奶不耐受（43.5% vs. 37.8%，p = 0.004）的患病率在大流行期间更高。许多人报告了多种症状。焦虑与所有 GI 症状的存在相关。高水平的压力会影响功能性消化不良（p = 0.045）和腹痛（p = 0.013）。存在 DGBI（p < 0.001；OR 22.99）、自我报告的牛奶不耐受（p < 0.001；OR 2.50）和焦虑（p < 0.001；OR 2.18）与 COVID-19 大流行期间 GI 症状的增加独立相关。
在 COVID-19 封锁期间，GI 症状的流行率明显高于前一年的正常情况。这种增加归因于 DGBI 患者人数的增加，而这种影响与焦虑有关。
