Spine Tumor Center, Department of Orthopedic Oncology, Changzheng Hospital, No. 415 Fengyang Road, Huangpu District, Shanghai, China.
Department of Anesthesiology, Changzheng Hospital, Shanghai, China.
Eur Spine J. 2021 Oct;30(10):2896-2905. doi: 10.1007/s00586-021-06896-z. Epub 2021 Jun 19.
Spinal ganglioneuroma (GN) is the most benign neoplasm of neuroblastic origin. There is little knowledge about spinal GN because of sporadic cases reported. The objective of this study is to describe the clinical manifestations and long-term follow-up outcomes of spinal GN after consecutive treatment.
The clinical and follow-up data of 31 patients with spinal GN receiving consecutive treatment in our institute are retrospectively analyzed.
The mean age of the 31 patients was 40.39 ± 14.8 years. They were diagnosed with spinal GN and received surgical treatment in our institution between February 2012 and August 2019. Of them, 22 (71%) patients presented preoperative neurological symptoms. The mean duration from symptom onset to surgery was 19.76 ± 49.59 months. Eighteen patients received complete surgical resection and 13 patients received subtotal excision. In addition, radicotomy was performed simultaneously after sophisticated consideration in 19 patients. The follow-up period averaged 64.13 ± 22.67 months. The preoperative neurological dysfunction was improved significantly during the follow-up period in all cases. No local recurrence or malignant transformation has occurred so far.
Spinal GN is a rare but benign neoplasm, and the origin of spinal GN remains controversial. With our experience, we propose that the origin of spinal GN from dorsal root ganglion should be equally considered as its counterpart of sympathetic ganglion. Complete resection is the preferred surgical strategy to avoid malignant events and recurrence. And the close postoperative follow-up observations are warranted.
神经节细胞瘤（GN）是最良性的神经母细胞瘤起源的肿瘤。由于报道的病例稀少，因此对脊柱 GN 的了解甚少。本研究的目的是描述连续治疗后脊柱 GN 的临床表现和长期随访结果。
回顾性分析我院连续治疗的 31 例脊柱 GN 患者的临床和随访资料。
31 例患者的平均年龄为 40.39±14.8 岁。他们在 2012 年 2 月至 2019 年 8 月期间在我院被诊断为脊柱 GN 并接受手术治疗。其中 22 例（71%）患者术前有神经症状。从症状出现到手术的平均时间为 19.76±49.59 个月。18 例患者接受了完全切除术，13 例患者接受了次全切除术。此外，19 例患者经过精细考虑后同时进行了椎板切开术。平均随访时间为 64.13±22.67 个月。所有病例的术前神经功能障碍在随访期间均有明显改善。迄今为止，尚未发生局部复发或恶性转化。
脊柱 GN 是一种罕见但良性的肿瘤，其起源仍存在争议。根据我们的经验，我们提出脊柱 GN 的起源应与交感神经节的起源同等考虑。完全切除是避免恶性事件和复发的首选手术策略。需要密切的术后随访观察。
