Meng Qing-Da, Ma Xiao-Ning, Wei Hong, Pan Rong-Hui, Jiang Wei, Chen Fang-Shu
Department of Pathology, Sixth People's Hospital of Jinan City, Zhangqiu, Shandong Province, China.
Department of Orthopedics, Sixth People's Hospital of Jinan City, Zhangqiu, Shandong Province, China.
Asian J Surg. 2016 Apr;39(2):116-9. doi: 10.1016/j.asjsur.2013.07.011. Epub 2013 Aug 24.
Lipomatous ganglioneuroma (LG) is a rare variant of ganglioneuroma that is histologically characterized by a mature adipocytic component admixed with a conventional ganglioneuroma. We report the clinicopathological and immunohistochemical features of an LG in a 44-year-old Chinese male; additionally, we review the literature regarding this type of tumor. Magnetic resonance imaging revealed a left paravertebral soft-tissue mass at the T11-L3 levels. Grossly, the encapsulated neoplasm had a white to yellowish cut surface and rubbery consistency. Microscopic evaluation revealed an encapsulated lesion that consisted of areas of ganglioneuroma admixed with areas of mature fat. By immunohistochemistry, the ganglion cells were positive for chromogranin and synaptophysin, whereas the Schwann cells were positive for vimentin, S-100 protein, and glial fibrillary acidic protein (GFAP). This is the second known report of a retroperitoneal LG. The patient was well and without evidence of disease at 2 years' follow-up.
脂肪性神经节细胞瘤（LG）是神经节细胞瘤的一种罕见变体，其组织学特征为成熟的脂肪细胞成分与传统神经节细胞瘤混合存在。我们报告了一名44岁中国男性患者的脂肪性神经节细胞瘤的临床病理及免疫组化特征；此外，我们还回顾了关于此类肿瘤的文献。磁共振成像显示在T11 - L3水平有一个左侧椎旁软组织肿块。大体上，包膜完整的肿瘤切面呈白色至淡黄色，质地似橡胶。显微镜评估显示一个包膜完整的病变，由神经节细胞瘤区域与成熟脂肪区域混合组成。免疫组化显示，神经节细胞嗜铬粒蛋白和突触素呈阳性，而施万细胞波形蛋白、S - 100蛋白和胶质纤维酸性蛋白（GFAP）呈阳性。这是第二例已知的腹膜后脂肪性神经节细胞瘤报告。患者在2年随访时情况良好，无疾病迹象。
