一名接受胺碘酮治疗的患者出现雷氏综合征样疾病。

Reye's syndrome-like illness in a patient receiving amiodarone.

作者信息

Jones D B, Mullick F G, Hoofnagle J H, Baranski B

机构信息

Liver Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.

出版信息

Am J Gastroenterol. 1988 Sep;83(9):967-9.

PMID:3414648

Abstract

A 16-yr-old boy who was receiving amiodarone for ventricular arrhythmias developed a Reye's syndrome-like illness several days after an upper respiratory infection. Liver biopsy revealed microvesicular fat and spotty hepatocellular necrosis, typical of Reye's syndrome. Recovery was complete. This case report suggests that medications other than aspirin may predispose to Reye's syndrome, and that children receiving amiodarone should receive prophylaxis against influenza B and chicken pox.

摘要

一名16岁男孩因室性心律失常正在接受胺碘酮治疗，在上呼吸道感染几天后出现了类似瑞氏综合征的疾病。肝脏活检显示有微泡脂肪和散在的肝细胞坏死，这是瑞氏综合征的典型表现。患儿完全康复。该病例报告提示，除阿司匹林外的其他药物可能诱发瑞氏综合征，接受胺碘酮治疗的儿童应预防乙型流感和水痘。