Technology and Process Development (TPD), WuXi Biologics, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai, 200131, China.
Technology and Process Development (TPD), WuXi Biologics, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai, 200131, China.
Protein Expr Purif. 2021 Oct;186:105930. doi: 10.1016/j.pep.2021.105930. Epub 2021 Jun 18.
Diamond MMC Mustang is a relatively new mixed-mode resin, which mediates both cation exchange and hydrophobic interactions. In this work, we evaluated this resin using Cytiva's Capto MMC ImpRes, a well-established mixed-mode resin with similar properties, as a benchmark. The data suggest that in comparison with Capto MMC ImpRes, Diamond MMC Mustang exhibits comparable binding capacity and resolution. In addition, the resin under evaluation shows good lot-to-lot consistency. The information provided in this study allows users to have additional options when selecting mixed-mode resin for intermediate purification or final polishing, which is favourable especially at the present time when the supply chains of many manufacturers are negatively impacted by the coronavirus pandemic.
Diamond MMC Mustang 是一种相对较新的混合模式树脂，同时介导阳离子交换和疏水相互作用。在这项工作中，我们使用 Cytiva 的 Capto MMC ImpRes 作为基准对该树脂进行了评估，Capto MMC ImpRes 是一种具有相似性能的成熟混合模式树脂。数据表明，与 Capto MMC ImpRes 相比，Diamond MMC Mustang 表现出相当的结合能力和分辨率。此外，所评估的树脂显示出良好的批间一致性。本研究提供的信息使用户在选择用于中间纯化或最终抛光的混合模式树脂时具有更多的选择，这在许多制造商的供应链因冠状病毒大流行而受到负面影响的情况下是有利的。
