Sexually Transmitted Disease Institute, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200443, China.
Department of Medical Mycology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200443, China.
J Mycol Med. 2021 Sep;31(3):101158. doi: 10.1016/j.mycmed.2021.101158. Epub 2021 May 26.
Candida parapsilosis is a rare cause of primary cutaneous infection, with rare cases reported in the literature to date, most of the reports were immunocompromised individuals. Herein, we report two cases of primary cutaneous infection caused by C. parapsilosis in immunocompetent adults. C. parapsilosis were isolated and identified through morphological and molecular analyses, these isolates were found to be susceptible to itraconazole through in vitro antifungal susceptibility test. Both patients achieved clinical relief following oral itraconazole treatment. These two cases enriched the manifestations of cutaneous C. parapsilosis and highlight the importance of early diagnose and treatment.
近平滑念珠菌是一种罕见的原发性皮肤感染病原体，目前文献中仅报道了少数病例，大多数报告的病例为免疫功能低下者。在此，我们报告两例免疫功能正常的成年人由近平滑念珠菌引起的原发性皮肤感染。通过形态学和分子分析分离和鉴定出近平滑念珠菌，这些分离株通过体外抗真菌药敏试验显示对伊曲康唑敏感。两例患者均经口服伊曲康唑治疗后获得临床缓解。这两个病例丰富了皮肤近平滑念珠菌感染的表现，并强调了早期诊断和治疗的重要性。
