Family Medicine Clinic, Obesity, Metabolism and Nutrition Center, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
Pusan National University School of Medicine, Yangsan, Republic of Korea.
Med Princ Pract. 2021;30(6):527-534. doi: 10.1159/000517909. Epub 2021 Jun 18.
The objective of this study is to evaluate irritable bowel syndrome (IBS) as a risk factor for osteoporosis and osteoporotic fracture in Korean women after controlling for basic confounding factors and considering detailed demographic and clinical information.
We performed a nationwide population-based retrospective cohort analysis and matched every IBS case with a non-IBS case at a 1:4 frequency ratio based on age. The population consisted of female patients with data in the Health Insurance Review and Assessment (HIRA) database from 2002 to 2010. To determine the risk of osteoporosis and osteoporotic fracture in IBS and non-IBS patients, hazard ratios (HRs) with 95% confidence intervals (CI) were estimated using Cox proportional hazards regression models, adjusting for confounding variables, such as the area of residence, health insurance type, and economic status.
We identified 1,017,468 patients in the HIRA database with data from 2002 to 2010 who could potentially be included in the cohort. Among these, we identified 1,545 (11.4%) women (age >19 years) with newly diagnosed IBS (IBS group). Additionally, 6,180 patients without IBS and age-matched to the IBS group were selected. Cox modeling revealed that the crude HRs for osteoporosis and osteoporotic fractures in patients with IBS were 1.476 (95% CI, 1.241-1.754) and 1.427 (95% CI, 1.086-1.876), respectively.
Our data showed an increased incidence of osteoporosis and osteoporotic fractures in women with IBS compared with age-matched controls.
本研究旨在评估肠易激综合征（IBS）是否为韩国女性骨质疏松症和骨质疏松性骨折的危险因素，研究在控制基本混杂因素并考虑详细的人口统计学和临床信息的情况下进行。
我们进行了一项全国性基于人群的回顾性队列分析，并根据年龄将每例 IBS 病例与 4 例非 IBS 病例进行 1:4 频数匹配。该人群由 2002 年至 2010 年 HIRA 数据库中具有数据的女性患者组成。为了确定 IBS 和非 IBS 患者发生骨质疏松症和骨质疏松性骨折的风险，使用 Cox 比例风险回归模型估计风险比（HR）及其 95%置信区间（CI），并调整混杂变量，如居住地、健康保险类型和经济状况。
我们从 2002 年至 2010 年的 HIRA 数据库中确定了 1017468 名患者，这些患者可能被纳入队列。在这些患者中，我们发现 1545 名（11.4%）年龄大于 19 岁的女性（IBS 组）患有新诊断的 IBS。此外，选择了 6180 名没有 IBS 且与 IBS 组年龄匹配的患者。Cox 模型显示，IBS 患者骨质疏松症和骨质疏松性骨折的粗 HR 分别为 1.476（95%CI，1.241-1.754）和 1.427（95%CI，1.086-1.876）。
与年龄匹配的对照组相比，我们的数据显示 IBS 女性发生骨质疏松症和骨质疏松性骨折的风险增加。
