Brescia Fabrizio, Pittiruti Mauro, Scoppettuolo Giancarlo, Zanier Chiara, Nadalini Elisa, Bottos Paola, Moreal Chiara, Da Ros Valentina, Fabiani Fabio
Unit of Anesthesia and Intensive Care Medicine, Vascular Access Team, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy.
Department of Surgery, Fondazione Policlinico Universitario "A.Gemelli" IRCCS, Rome, Italy.
J Vasc Access. 2023 Jan;24(1):87-91. doi: 10.1177/11297298211026453. Epub 2021 Jun 19.
Taurolidine lock is known to be effective in preventing catheter-related infections in a variety of venous access devices, including long term venous access devices for chemotherapy. Though, literature about the use of taurolidine for treating catheter colonization or catheter-related blood stream infection is scarce.
We have retrospectively reviewed the safety and efficacy of 2% taurolidine lock for treatment of catheter-colonization and of catheter-related bloodstream infection in cancer patients with totally implanted venous access devices. Diagnosis of colonization or catheter-related infection was based on paired peripheral and central blood cultures, according to the method of Delayed Time to Positivity.
We recorded 24 cases of catheter-related infection and two cases of colonization. Taurolidine lock-associated with systemic antibiotic therapy-was successful in treating all cases of catheter-related infection, with disappearance of clinical symptoms, normalization of laboratory values, and eventually negative blood cultures. Taurolidine lock was also safe and effective in treating device colonization. No adverse effect was reported.
In our retrospective analysis, 2% taurolidine lock was completely safe and highly effective in the treatment of both catheter-colonization and catheter-related bloodstream infection in cancer patients with totally implanted venous access devices.
已知牛磺罗定封管在预防包括化疗用长期静脉通路装置在内的各种静脉通路装置相关感染方面是有效的。然而，关于使用牛磺罗定治疗导管定植或导管相关血流感染的文献却很匮乏。
我们回顾性分析了2%牛磺罗定封管治疗完全植入式静脉通路装置的癌症患者导管定植和导管相关血流感染的安全性和有效性。根据延迟阳性时间法，通过配对的外周血和中心血培养来诊断定植或导管相关感染。
我们记录了24例导管相关感染病例和2例定植病例。与全身抗生素治疗联合使用的牛磺罗定封管成功治疗了所有导管相关感染病例，临床症状消失，实验室值恢复正常，最终血培养转阴。牛磺罗定封管在治疗装置定植方面也是安全有效的。未报告不良反应。
在我们的回顾性分析中，2%牛磺罗定封管在治疗完全植入式静脉通路装置的癌症患者的导管定植和导管相关血流感染方面完全安全且高效。
