Department of Internal Medicine A, Mohammed V Military Instruction Hospital, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco.
Department of Radiology, Mohammed V Military Instruction Hospital, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University Rabat, Morocco.
Mo Med. 2021 May-Jun;118(3):226-232.
Chronic active Epstein-Barr virus infection is a rare disease with an often fatal outcome. Cardiovascular complications are associated with a poor prognosis. We herein describe the clinical course of an adult patient with Epstein-Barr virus-associated systemic vasculitis complicated by multi-systemic aneurysmal disease. The vascular imaging showed multiple aneurysms involving coronary arteries, abdominal arteries, cerebral arteries, and vertebral arteries. Immunophenotyping analysis of peripheral blood lymphocytes revealed the presence of an increased number of double negative T cells. The patient received multiple lines of immunosuppressive therapy with no response. Unfortunately, he succumbed to a cerebral aneurysm rupture.
慢性活动性 EBV 感染是一种罕见疾病，常导致致命后果。心血管并发症与预后不良相关。本文描述了一例 EBV 相关系统性血管炎合并多系统动脉瘤病的成年患者的临床经过。血管成像显示多个动脉瘤累及冠状动脉、腹主动脉、脑动脉和椎动脉。外周血淋巴细胞免疫表型分析显示双阴性 T 细胞数量增加。患者接受了多线免疫抑制治疗，但均无反应。不幸的是，他死于脑动脉瘤破裂。
