Department of Critical Care Units, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Infectious Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Immunol. 2021 Feb 25;12:618830. doi: 10.3389/fimmu.2021.618830. eCollection 2021.
Encephalitis caused by Epstein-Barr virus infection is uncommon, but most patients have a good outcome after symptomatic treatment. The infiltration of mononuclear cells in blood vessels and necrosis resulting from the immune response to Epstein-Barr virus infection in a very small number of patients seem to be the main cause of death. We describe a fatal case of Epstein-Barr virus encephalitis diagnosed by next-generation sequencing in an immune-competent adult but progressed to brainstem hemorrhage.
由 Epstein-Barr 病毒感染引起的脑炎并不常见,但大多数患者在对症治疗后预后良好。极少数患者由于对 Epstein-Barr 病毒感染的免疫反应导致血管内单核细胞浸润和坏死,似乎是死亡的主要原因。我们描述了一例免疫功能正常的成年患者通过下一代测序诊断为致命性 Epstein-Barr 病毒脑炎,但进展为脑干出血。