Jureczko Marcelina, Przystaś Wioletta
Environmental Biotechnology Department, Faculty of Energy and Environmental Engineering, The Silesian University of Technology, Akademicka 2, 44-100 Gliwice, Poland.
The Biotechnology Centre, The Silesian University of Technology, Krzywoustego 8, 44-100 Gliwice, Poland.
J Environ Health Sci Eng. 2021 Mar 5;19(1):651-662. doi: 10.1007/s40201-021-00635-8. eCollection 2021 Jun.
Cytostatic drugs cannot be easily removed by conventional sewage treatment plants, resulting in their ultimate release into aquatic systems where they become a threat. Thus, new technologies which can be used to eliminate these drugs more effectively before they enter the environment are increasingly important. Fungal treatment of wastewaters is a promising and environmentally friendly technology for pharmaceutical remediation. The aim of this work is to examine the biosorption of two cytostatics, bleomycin and vincristine, in the aqueous solution by fungal biomass.
Five white-rot fungi were used in this study: (CB13), (CB15), (CB14), (BWPH), and (CB8). Tests were conducted on different types of biomass (alive and dead - autoclaved) and in various physico-chemical conditions: varied drug concentrations (5, 10 and 15 mg/L), temperatures (from 15.4 to 29.6 °C), and pH (from 3.2 to 8.8).
The results showed that among alive biomass, (CB8) had the greatest sorption ability for bleomycin and (CB14) worked best for vincristine. The tested sorption process could be described by a pseudo-second order kinetics model. Sorption equilibrium studies demonstrated that for bleomycin Redlich-Peterson, while for vincristine Langmuir model fitted best. The thermodynamic studies showed that the sorption process was endothermic chemisorption for bleomycin, and exothermic physisorption for vincristine. For both drugs the sorption ability increased with an increase of the pH value.
The biosorption on fungal biomass is a favorable alternative to conventional wastewater treatment processes for anticancer drug removal.
细胞抑制药物不易被传统污水处理厂去除，最终会释放到水生系统中，对其造成威胁。因此，在这些药物进入环境之前能够更有效消除它们的新技术变得越来越重要。真菌处理废水是一种有前景且环保的药物修复技术。本研究的目的是考察真菌生物质对水溶液中两种细胞抑制药物博来霉素和长春新碱的生物吸附作用。
本研究使用了五种白腐真菌：（CB13）、（CB15）、（CB14）、（BWPH）和（CB8）。对不同类型的生物质（活的和经高压灭菌死亡的）以及各种物理化学条件进行了测试：不同的药物浓度（5、10和15毫克/升）、温度（15.4至29.6摄氏度）和pH值（3.2至8.8）。
结果表明，在活生物质中，（CB8）对博来霉素的吸附能力最强，（CB14）对长春新碱的吸附效果最佳。所测试的吸附过程可用伪二级动力学模型来描述。吸附平衡研究表明，博来霉素符合Redlich-Peterson模型，而长春新碱最适合Langmuir模型。热力学研究表明，博来霉素的吸附过程是吸热化学吸附，长春新碱的吸附过程是放热物理吸附。对于这两种药物，吸附能力均随pH值的升高而增加。
真菌生物质上的生物吸附是去除抗癌药物的传统废水处理工艺的一种有利替代方法。
