Riaz Amir, Khan Sikandar, Miret Rafael, Bejarano Pablo, Ur Rahman Asad
Internal Medicine, Cleveland Clinic Florida, Weston, USA.
Pathology, Cleveland Clinic Florida, Weston, USA.
Cureus. 2021 May 15;13(5):e15045. doi: 10.7759/cureus.15045.
The co-occurrence of autoimmune hepatitis (AIH) and pernicious anemia (PA) is extremely rare. We present a case of a 70-year-old woman with AIH who presented for the evaluation of poor appetite and weight loss. Laboratory studies were significant for microcytic anemia, B12, and iron deficiency. Esophagogastroduodenoscopy showed diffuse gastric mucosal atrophy, and the pathology from the body of the stomach showed chronic gastritis. Additional testing was positive for parietal cell antibody and intrinsic factor blocking antibody, confirming the diagnosis of PA. To the best of our knowledge, there is only one documented case of AIH associated with PA.
自身免疫性肝炎（AIH）与恶性贫血（PA）同时出现极为罕见。我们报告一例70岁患有AIH的女性病例，该患者因食欲减退和体重减轻前来评估。实验室检查显示小细胞贫血、维生素B12和铁缺乏。食管胃十二指肠镜检查显示弥漫性胃黏膜萎缩，胃体部病理显示慢性胃炎。进一步检测壁细胞抗体和内因子阻断抗体呈阳性，确诊为PA。据我们所知，仅有一例AIH与PA相关的记录病例。
