Ali Hassan, Ismail Ahmed Abdelaziz, Wahdan Amr Samir
Anesthesia Department, Cairo University, Cairo, Egypt.
Anesth Pain Med. 2020 Dec 19;10(6):e108469. doi: 10.5812/aapm.108469. eCollection 2020 Dec.
With the increased number of abdominoplasty all over the world, and the need to manage postoperative pain, it is a must to find proper and effective drugs to decrease opioid consumption in the postoperative period.
In this double-blind randomized controlled clinical trial, we assumed that low-dose ketamine infusion will reduce the postoperative pain profile than the conventional method of morphine.
The scheduled patients for abdominoplasty under general anesthesia were recruited in two groups: group (K) with low-dose ketamine infusion intra-operatively (80 patients) and group (M) with morphine infusion intra-operatively (80 patients). Both groups were monitored intraoperatively and postoperatively for rescue doses of fentanyl, visual analogue scale (VAS), and side effects.
There were no statistical differences between both groups regarding the fentanyl rescue doses intra- and postoperative with no remarkable side effects.
Low-dose ketamine has a useful analgesic effect in abdominoplasty similar to morphine without remarkable side effects, such as sedation or hallucinations.
随着全球腹壁成形术数量的增加，以及管理术后疼痛的需求，必须找到合适且有效的药物以减少术后阿片类药物的使用量。
在这项双盲随机对照临床试验中，我们假设术中输注低剂量氯胺酮比传统的吗啡方法能降低术后疼痛程度。
将计划在全身麻醉下进行腹壁成形术的患者分为两组：术中输注低剂量氯胺酮的组（K组，80例患者）和术中输注吗啡的组（M组，80例患者）。两组在术中和术后均监测芬太尼的抢救剂量、视觉模拟评分（VAS）及副作用。
两组在术中和术后芬太尼抢救剂量方面无统计学差异，且无明显副作用。
低剂量氯胺酮在腹壁成形术中具有与吗啡相似的有效镇痛作用，且无明显副作用，如镇静或幻觉。
