Fritz W, Engst R, Shabad L M, Dikun P P, Khesine A Ia
Vopr Pitan. 1977 Nov-Dec(6):71-5.
The article is the first in a series of joint publications relating to work carried out in the USSR and GDR in studying possible carcinogenicity of alimentary products and pertinent preventive measures to exclude it. It contains brief information on the effect produced by carcinogenic additives in nutritional products upon the cancer involving the gastro-intestinal tract (in workers of meat packing plants and smokehouses). Under discussion is the relation between the disease-incidence and nutritional specificity. Major sources of possible carcinogenicity of alimentary products, such as additions of some dyestuffs, admixtures of some natural substances (cycsdine, thiourea, etc), contaminations of biological origin, with mycotoxins, carcinogens finding their way from the environment and, what is most important caused by specific technology of manufacturing the nutritional product (smoking, direct drying, frying, etc) are considered. The significance of carcinogenic PAH and benzpyrene, nitrose-amines and mycotoxins is discussed. The possibility and the need for determining carcinogenic compounds, of PAH above all, and their technical limitations in alimentary products with a view of preventing cancer of the gastro-intestinal tract are considered.
本文是一系列联合出版物中的第一篇,这些出版物涉及苏联和民主德国在研究食品可能的致癌性以及排除致癌性的相关预防措施方面所开展的工作。它包含了关于营养产品中致癌添加剂对胃肠道癌症(在肉类加工厂和熏制厂工人中)产生的影响的简要信息。文中讨论了发病率与营养特性之间的关系。还考虑了食品可能致癌的主要来源,例如某些染料的添加、一些天然物质(环丝氨酸、硫脲等)的混合物、生物源性污染(霉菌毒素)、来自环境的致癌物,以及最重要的由营养产品特定制造工艺(烟熏、直接干燥、油炸等)导致的致癌物。文中讨论了致癌性多环芳烃和苯并芘、亚硝胺和霉菌毒素的重要性。考虑了测定致癌化合物(首先是多环芳烃)的可能性和必要性,以及在食品中测定这些化合物的技术局限性,以期预防胃肠道癌症。