Fritz W, Engst R, Shabad L M, Dikun P P, Khesina J
Arch Geschwulstforsch. 1977;47(6):561-6.
Investigations on the relationship of the environmental contamination with cancer are shown to be necessary. Epidemiologic investigations point to a connection of the increased occurence of cancer in the gastro-intestinal tract with dietetic factors. The high cancer rate in the gastro-intestinal tract (amongst other factors) is discussed as a result of the uptake of exogenic foreign matterns with the food. The possibilities of the contamination by cancerogenic compounds are summarized. The necessity of international co-operation in the field of finding out, as far as possible, sources and degree of food contamination by cancerogenic compounds is motivated beginning with polycyclic aromatic compounds, whereby at present benzo-(a)-pyrene comes into question as a reference substance. The laying down of controllable hygienic norms as preliminarily tolerable limits in the proper sense of an unavoidable dose are discussed. They could be a basis of oncological preventive measures (minimization or elimination of cancerogenic compounds in foods).
对环境污染与癌症之间关系的调查表明是必要的。流行病学调查指出胃肠道癌症发病率的增加与饮食因素有关。胃肠道的高癌症发病率(除其他因素外)被认为是由于食物中摄入外源性异物所致。总结了致癌化合物污染的可能性。从多环芳烃开始,阐述了在尽可能查明致癌化合物对食物的污染来源和程度方面进行国际合作的必要性,目前苯并(a)芘被视为参考物质。讨论了制定可控卫生规范作为不可避免剂量意义上的初步可容忍限度。它们可以作为肿瘤预防措施(减少或消除食品中的致癌化合物)的基础。