Okamoto T, Masahashi T, Ogawa A, Higuchi K, Sawaguchi K, Yabushita H, Noguchi M, Ishihara M
Dept. of Obstetrics and Gynecology, Aichi Medical University.
Gan To Kagaku Ryoho. 1988 Aug;15(8 Pt 2):2448-52.
Three patients with advanced cervical carcinoma were treated with two courses of cis-platinum (CDDP) intra-arterial administration. Histology of all patients revealed squamous cell carcinoma, keratinizing type, and all patients had stage IIIb diseases. CDDP at a dose of 50 mg was infused through each catheter of which tips were fixed in the bilateral internal iliac arteries via the opposite femoral arteries. The course of therapy was repeated at an interval of three to four weeks, so the total dose of CDDP in each patient was 200 mg. The bleeding from lesions, which occurred intermittently before therapy in all patients, was reduced after the primary course of therapy and completely stopped after the second one. Marked reduction of lesion on computed tomograph (CT) was confirmed in all patients. The reduction in the product of perpendicular diameters of measurable lesions on CT ranged from 40 to 50%. Adverse effects such as nephrotoxicity, myelosuppression and gastrointestinal toxicity were mild as compared with patients receiving intravenous administration of CDDP. The excellent clinical effects and tolerance observed in this study indicated that an intra-arterial administration of CDDP has a highly therapeutic efficacy in the treatment of squamous cell carcinoma of the cervix.
三名晚期宫颈癌患者接受了两疗程的顺铂（CDDP）动脉内给药治疗。所有患者的组织学检查均显示为角化型鳞状细胞癌，且所有患者均为Ⅲb期疾病。通过分别经对侧股动脉将导管尖端固定于双侧髂内动脉的方式，以50mg的剂量注入CDDP。治疗疗程每隔三到四周重复一次，因此每位患者的CDDP总剂量为200mg。所有患者在治疗前均间歇性出现病变部位出血，在第一疗程治疗后出血减少，第二疗程后完全停止。所有患者的计算机断层扫描（CT）均证实病变明显缩小。CT上可测量病变垂直径乘积的缩小范围为40%至50%。与接受CDDP静脉给药的患者相比，肾毒性、骨髓抑制和胃肠道毒性等不良反应较轻。本研究中观察到的优异临床效果和耐受性表明，CDDP动脉内给药在治疗宫颈鳞状细胞癌方面具有很高的治疗效果。
