Ackerman Z, Seidenbaum M, Loewenthal E, Rubinow A
Department of Internal Medicine, Hadassah University Hospital, Jerusalem.
Arch Dermatol. 1988 Sep;124(9):1376-8.
The brown pigmentation of the skin associated with venous ulceration is caused by increased local iron deposition. Diagnostic x-ray spectrometry, a method based on x-ray fluorescence analysis, was used for the noninvasive determination of iron levels in the skin of patients with venous ulceration. The mean (+/- SEM) iron concentration in the skin around the venous ulcer was elevated, compared with control values of nonulcerated skin (250 +/- 54 vs 128 +/- 39 micrograms) and compared with normal skin from the forearm (250 +/- 54 vs 14 +/- 2.5 micrograms). These data suggest that dermal iron deposition may not be an incidental by-product of increased venous pressure, but may actively perpetuate tissue damage in venous ulcerations.
与静脉溃疡相关的皮肤褐色色素沉着是由局部铁沉积增加所致。诊断性X射线光谱测定法是一种基于X射线荧光分析的方法，用于无创测定静脉溃疡患者皮肤中的铁含量。与未溃疡皮肤的对照值（250±54 vs 128±39微克）以及与前臂正常皮肤（250±54 vs 14±2.5微克）相比，静脉溃疡周围皮肤中的平均（±SEM）铁浓度升高。这些数据表明，真皮铁沉积可能不是静脉压升高的偶然副产品，而是可能在静脉溃疡中积极地使组织损伤持续存在。
