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腹部创伤后胰腺手术后期发病率和死亡率分析

Analysis of Later Stage Morbidity and Mortality after Pancreatic Surgery Because of Abdominal Trauma.

作者信息

Huajian Ren, Qiongyuan Hu, Gefei Wang, Guosheng Gu, Jun Chen, Zhiwu Hong, Yanhan Ren, Mahmood Gulrez, Sawyer Robert G, Jianan Ren

机构信息

Department of General Surgery, Jinling Hospital, Jiangsu Nanjing, China.

Chicago Medical School, Rosalind Franklin University of Medicine and Science, Chicago, Illinois, USA.

出版信息

Surg Infect (Larchmt). 2021 Dec;22(10):1031-1038. doi: 10.1089/sur.2020.246. Epub 2021 Jun 21.

DOI:10.1089/sur.2020.246
PMID:34152863
Abstract

Pancreatic trauma surgery is a complicated surgical procedure for severe pancreatic injuries, accompanied by a high incidence of complications and mortality. This study was designed to explore the long-term prognosis of pancreatic surgery because of abdominal trauma. The clinical data of 103 patients who were admitted to Jinling Hospital between August 2012 and August 2019 who had pancreatic trauma surgery were analyzed retrospectively. All admissions involved pancreatic trauma surgery performed at an outside hospital network, which later transferred patients to our institution because of post-operative later-stage complications. Eight patients received American Association for the Surgery of Trauma (AAST) grade 1 or 2 pancreatic injuries and 95 received AAST grade 3, 4, or 5 pancreatic injuries. The primary surgical management of pancreatic injuries included drainage of the pancreatic injury (n = 28), repair of the pancreas (n = 35), partial pancreatectomy (n = 15), pancreaticojejunostomy (n = 6), and pancreaticoduodenectomy (n = 19). The most common mechanism of trauma was motor vehicle collision (n = 72), crush injury (n = 26), and stab wound (n = 5). Of 103 patients suffered varying degrees of gastrointestinal fistulae and intra-abdominal infections, there were 66 cases of pancreatic fistulae (64.1%), 49 cases of enteric fistulae (47.6%), 26 cases of colonic fistulae (25.2%), 14 cases of gastric or gastrointestinal anastomotic fistulae (13.6%), and 13 cases of biliary fistulae (12.6%). Ninety-five patients survived and eight patients died after therapy; the mean length of intensive care unit stay was 33 days. The number of patients who underwent emergency pancreaticoduodenectomy (EPD), the incidence of blood transfusion, the number of fistulae per patient, and the duration of mechanical ventilation and bacteremia in the mortality group were substantially higher than in the survival group (p < 0.05 each). The patients who underwent EPD had more grade 5 pancreatic injuries, more blood transfusions, higher peak total bilirubin, greater numbers of fistulae and open abdomen, and longer duration of mechanical ventilation and mortality than other patients (p < 0.05 each). The grade of pancreatic injury was associated with mortality and post-operative complications. The post-operative mortality and occurrence of complications of EPD because of abdominal trauma were significant; use of damage control surgery could potentially reduce the morbidity and mortality related to this procedure.

摘要

胰腺创伤手术是针对严重胰腺损伤的复杂外科手术,并发症发生率和死亡率都很高。本研究旨在探讨腹部创伤所致胰腺手术的长期预后。回顾性分析了2012年8月至2019年8月间在金陵医院接受胰腺创伤手术的103例患者的临床资料。所有患者均在外部医院网络接受了胰腺创伤手术,后来因术后晚期并发症被转至我院。8例患者为美国创伤外科学会(AAST)1级或2级胰腺损伤,95例为AAST 3级、4级或5级胰腺损伤。胰腺损伤的主要手术处理方式包括胰腺损伤引流(n = 28)、胰腺修复(n = 35)、部分胰腺切除术(n = 15)、胰空肠吻合术(n = 6)和胰十二指肠切除术(n = 19)。最常见的创伤机制是机动车碰撞(n = 72)、挤压伤(n = 26)和刺伤(n = 5)。103例患者均有不同程度的胃肠瘘和腹腔内感染,其中胰瘘66例(64.1%)、肠瘘49例(47.6%)、结肠瘘26例(25.2%)、胃或胃肠吻合口瘘14例(13.6%)、胆瘘13例(12.6%)。95例患者经治疗后存活,8例死亡;重症监护病房平均住院时间为33天。死亡组患者接受急诊胰十二指肠切除术(EPD)的人数、输血发生率、每位患者的瘘管数、机械通气时间和菌血症持续时间均显著高于存活组(均p < 0.05)。接受EPD的患者比其他患者有更多的5级胰腺损伤、更多的输血、更高的总胆红素峰值、更多的瘘管和开腹情况,机械通气时间和死亡率也更长(均p < 0.05)。胰腺损伤的分级与死亡率及术后并发症相关。腹部创伤所致EPD的术后死亡率和并发症发生率均较高;采用损伤控制手术可能会降低与此手术相关的发病率和死亡率。

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