心脏移植后心肺运动试验的预后价值。

Prognostic value of cardiopulmonary exercise test after heart transplantation.

机构信息

Cardiology Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Cardiovascular Surgery Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

出版信息

Clin Transplant. 2021 Aug;35(8):e14387. doi: 10.1111/ctr.14387. Epub 2021 Jun 28.

DOI:10.1111/ctr.14387

PMID:34153128

Abstract

BACKGROUND

The clinical utility of cardiopulmonary exercise testing (CPET) has not been extensively studied yet in heart transplantation (HTX) patients.

OBJECTIVE

To analyze the predictive value of the CPET on hospitalizations and mortality in HTX recipients.

METHODS

A retrospective cohort was performed from a secondary database. Patients > 18 years with HTX who underwent a CPET between 3 and 12 months after transplantation were included. Time to the first primary endpoint (HTX-related hospitalization) was analyzed and adjusted using Cox proportional hazards regression model.

RESULTS

A total of 122 patients (mean age 50.1 years, 77.0% men) were included. Fifty-seven patients (46.7%) had the primary endpoint. Peak VO (HR .95; CI 95% .90-.99, P = .03), oxygen pulse (HR .57; CI 95% .34-.96, P = .03) and predicted VO (HR .97; CI 95% .96-.99, P = .002) were associated with the endpoint. We did not find a significant association between the other variables and the outcome.

CONCLUSION

In HTX recipients, peak VO , oxygen pulse, and predicted VO were independently associated with hospitalizations at follow up.

摘要

背景

心肺运动测试（CPET）在心脏移植（HTX）患者中的临床应用尚未得到广泛研究。

目的

分析 CPET 在 HTX 受者住院和死亡中的预测价值。

方法

从二级数据库中进行回顾性队列研究。纳入年龄>18 岁、移植后 3 至 12 个月内接受 CPET 的 HTX 患者。使用 Cox 比例风险回归模型分析并调整首次主要终点（与 HTX 相关的住院）的时间。

结果

共纳入 122 例患者（平均年龄 50.1 岁，77.0%为男性）。57 例患者（46.7%）发生主要终点。峰值 VO（HR.95；95%CI.90-.99，P=.03）、氧脉搏（HR.57；95%CI.34-.96，P=.03）和预测 VO（HR.97；95%CI.96-.99，P=.002）与终点相关。我们没有发现其他变量与结果之间存在显著关联。