Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Microb Pathog. 2021 Sep;158:105058. doi: 10.1016/j.micpath.2021.105058. Epub 2021 Jun 18.
The small (4.5-5kbp), double-stranded Trichomonas vaginalis virus (TVV) that inhabits in the T. vaginalis parasite has been potentially associated to parasite virulence or its drug resistance. The aim of present study was to estimate the global and regional status of TVV in T. vaginalis.
A systematic search was conducted for published articles between January 1990 and December 2020 by using five major databases include PubMed, Embase, Scopus, and Web of Science as well as Google scholar search engine. The random-effect model was applied for pooled prevalence of TVV, geographical distribution, and heterogeneity by comprehensive meta-analysis (V2.2, Bio stat) software.
A total of 28 studies were included for final meta-analysis. The pooled prevalence of TVV was estimated at 47% (95% CI, 39.3-54.8%). With respect to WHO regions, the lowest and highest prevalence rates were reported from South-East Asia 23% (95% CI, 12-41%) and African 66% (95% CI, 25-92%), respectively. Considering the countries, the prevalence was highest in the Brazil 90% (95% CI, 73-97%) and lowest in the South Korea 14% (95% CI, 4-35%).
The high prevalence of the parasitic virus emphasizes the need to pay attention to the behavior of the parasite, both in terms of clinical symptoms and drug resistance. Moreover, it is suggested that more studies (i.e. in vitro, in vivo, and case-control studies) should be conducted for deep understanding of this coexistence.
寄生于阴道毛滴虫中的小（4.5-5kbp）双链阴道毛滴虫病毒（TVV）可能与寄生虫的毒力或耐药性有关。本研究旨在评估全球和区域阴道毛滴虫中 TVV 的状况。
通过使用五个主要数据库（包括 PubMed、Embase、Scopus、Web of Science 和 Google Scholar 搜索引擎）对 1990 年 1 月至 2020 年 12 月期间发表的文章进行系统检索。采用综合荟萃分析（V2.2，Bio stat）软件的随机效应模型对 TVV 的全球和区域流行率、地理分布和异质性进行荟萃分析。
共有 28 项研究纳入最终荟萃分析。TVV 的总流行率估计为 47%（95%CI，39.3-54.8%）。按世卫组织区域划分，东南亚报道的最低和最高流行率分别为 23%（95%CI，12-41%）和 66%（95%CI，25-92%）。就国家而言，巴西的流行率最高，为 90%（95%CI，73-97%），韩国的流行率最低，为 14%（95%CI，4-35%）。
寄生虫病毒的高流行率强调需要关注寄生虫的行为，无论是在临床症状还是药物耐药性方面。此外，建议进行更多的研究（即体外、体内和病例对照研究），以深入了解这种共存关系。
