Dilman V M, Berstein L M, Yevtushenko T P, Tsyrlina Y V, Ostroumova M N, Kovalenko I G, Simonov N N
N. N. Petrov Research Institute of Oncology, USSR Ministry of Health, Leningrad.
Arch Geschwulstforsch. 1988;58(3):175-83.
Pathways of metabolic rehabilitation of cancer patients are discussed. The effectiveness of a long-term carbohydrate, fat and cholesterol restricted diet and hypolipidemic and antidiabetic medication for breast, gastric and colorectal cancers was demonstrated for the first time. The results of gastro-intestinal cancer treatment were especially encouraging. Metabolic rehabilitation chiefly resulted in a lower frequency of metastatic spread. Also, its effect was seen in a rarer primary multiple tumor development. The results make a case for further development of investigations in normalizing fat-carbohydrate metabolism as adjuvant therapy for cancer in postoperative period.
本文讨论了癌症患者的代谢康复途径。首次证明了长期限制碳水化合物、脂肪和胆固醇的饮食以及降血脂和抗糖尿病药物对乳腺癌、胃癌和结直肠癌的有效性。胃肠道癌症的治疗结果尤其令人鼓舞。代谢康复主要导致转移扩散的频率降低。此外，在罕见的原发性多发性肿瘤发展中也可见其效果。这些结果为进一步开展研究以将脂肪-碳水化合物代谢正常化作为癌症术后辅助治疗提供了依据。
