血清胃抑制多肽（GIP）、可溶性白细胞介素-2 受体（sIL-2R）和髓系细胞表达的触发受体-1（sTREM-1）水平与重症急性胰腺炎患者的病情和预后的关系。

Relationship between levels of serum gastric inhibitory polypeptide (GIP), soluble interleukin-2 receptor (sIL-2R), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and disease condition and prognosis of patients with severe acute pancreatitis.

机构信息

Department of Nursing, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Chinese Academy of Sciences, Sichuan Translational Medicine Research Hospital, Chengdu, China; Department of Nursing, Chengdu Qing Cheng Mt. Hospital, Chengdu, China.

出版信息

Ann Palliat Med. 2021 Jun;10(6):6786-6792. doi: 10.21037/apm-21-1231. Epub 2021 Jun 11.

DOI:10.21037/apm-21-1231

PMID:34154356

Abstract

BACKGROUND

To explore the relationship between levels of serum gastric inhibitory polypeptide (GIP), soluble interleukin-2 receptor (sIL-2R), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and the disease condition and prognosis in patients with severe acute pancreatitis (SAP).

METHODS

A total of 52 patients with SAP (SAP group) and 50 patients with mild acute pancreatitis (MAP group) admitted to Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China between April 2017 and December 2019 were included in the present study. A further 50 people who had received a healthy physical examination during the same period constituted the healthy control group. The levels of serum GIP, sIL-2R, and sTREM-1 were measured. The levels of serum GIP, sIL-2R, and sTREM-1 were compared among the SAP, MAP and healthy control groups, and the severity of disease (Ranson scoring system) was compared between the SAP and MAP groups. Pearson correlation analysis was used to analyze the correlation between the levels of serum GIP, sIL-2R, and sTREM-1 with the Ranson scores in the SAP group. A receiver operating characteristic (ROC) curve was drawn to evaluate the predictive efficacy of serum GIP, sIL-2R, and sTREM-1 on prognosis.

RESULTS

The levels of serum GIP, sIL-2R, and sTREM-1 in the SAP and MAP groups were higher than those in the healthy control group, and the levels in the SAP group were higher than those in the MAP group. The Pearson correlation analysis showed that the levels of serum GIP, sIL-2R, and sTREM-1 in the SAP group were positively correlated with Ranson scores. The levels of serum GIP, sIL-2R, and sTREM-1 in the survival group were lower than those in the deceased group. The ROC curve showed that the best cut-off values of serum GIP, sIL-2R, and sTREM-1 in predicting prognostic survival were 167.040 pg/mL, 70.840 pg/mL, and 128.325 ng/mL, respectively.

CONCLUSIONS

The levels of serum GIP, sIL-2R, and sTREM-1 are closely related to the severity of illness in patients with SAP and can be used as reference indicators for assessing the onset of SAP and predicting prognosis.

摘要

背景

探讨血清胃抑制多肽（GIP）、可溶性白细胞介素-2 受体（sIL-2R）和髓系细胞触发受体-1 可溶性（sTREM-1）水平与重症急性胰腺炎（SAP）患者病情和预后的关系。

方法

选取 2017 年 4 月至 2019 年 12 月在电子科技大学四川省人民医院收治的 52 例 SAP 患者（SAP 组）和 50 例轻症急性胰腺炎（MAP）患者（MAP 组），另选取同期健康体检者 50 例作为健康对照组。检测血清 GIP、sIL-2R 和 sTREM-1 水平，比较 SAP 组、MAP 组和健康对照组的血清 GIP、sIL-2R 和 sTREM-1 水平，比较 SAP 组和 MAP 组的疾病严重程度（Ranson 评分系统）。采用 Pearson 相关分析评估 SAP 组患者血清 GIP、sIL-2R 和 sTREM-1 水平与 Ranson 评分的相关性。绘制受试者工作特征（ROC）曲线，评价血清 GIP、sIL-2R 和 sTREM-1 对预后的预测效果。

结果

SAP 组和 MAP 组血清 GIP、sIL-2R 和 sTREM-1 水平均高于健康对照组，SAP 组高于 MAP 组。Pearson 相关分析显示，SAP 组患者血清 GIP、sIL-2R 和 sTREM-1 水平与 Ranson 评分呈正相关。存活组患者血清 GIP、sIL-2R 和 sTREM-1 水平均低于死亡组。ROC 曲线显示，血清 GIP、sIL-2R 和 sTREM-1 预测预后生存的最佳截断值分别为 167.040 pg/ml、70.840 pg/ml 和 128.325 ng/ml。