Zersen Kristin M, Molli Angela, Weisbeck Brooke G, Fedotova Samantha, Quimby Jessica M, Gustafson Daniel L, Shropshire Sarah B
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, The Ohio State University, Columbus, OH 43210, USA.
Vet Sci. 2024 Mar 3;11(3):112. doi: 10.3390/vetsci11030112.
The purpose of this study was to evaluate plasma ondansetron (OND) concentrations in a population of dogs with naturally occurring nausea after oral OND administration. Twenty-four dogs were randomly assigned to receive one of the following doses of oral OND: 0.5 mg/kg q8h, 0.5 mg/kg q12h, 1 mg/kg q8h, or 1 mg/kg q12h. Blood samples for plasma OND measurements were collected at baseline and 2, 4, and 8 h after administration of the first dose of OND. OND concentrations averaged over an 8 h time period were not significantly different between dose groups (0.5 mg/kg group: median 8.5 ng/mL [range 1-96.8 ng/mL], 1 mg/kg group: median 7.4 ng/mL [range 1-278.7 ng/mL]). The mean maximum concentrations in the 0.5 mg/kg and 1 mg/kg groups were 35.8 ± 49.0 ng/mL and 63.3 ± 121.1 ng/mL, respectively. OND concentrations were below the lower limit of quantification (LLOQ) in 50% (18/36) of samples in the 0.5 mg/kg groups and 39% (14/36) of samples in the 1 mg/kg groups. Six dogs (6/24, 25%) did not have OND detected at any time. The mean nausea scores at baseline were similar amongst all groups and decreased over time. The bioavailability of oral OND appears to be poor. Despite low plasma OND concentrations, nausea scores improved over time.
本研究的目的是评估口服昂丹司琼（OND）后自然发生恶心的犬群体中的血浆昂丹司琼（OND）浓度。24只犬被随机分配接受以下口服OND剂量之一：0.5mg/kg每8小时一次、0.5mg/kg每12小时一次、1mg/kg每8小时一次或1mg/kg每12小时一次。在基线以及首次给予OND后2、4和8小时采集用于血浆OND测量的血样。各剂量组在8小时时间段内的OND浓度平均值无显著差异（0.5mg/kg组：中位数8.5ng/mL[范围1 - 96.8ng/mL]，1mg/kg组：中位数7.4ng/mL[范围1 - 278.7ng/mL]）。0.5mg/kg组和1mg/kg组的平均最大浓度分别为35.8±49.0ng/mL和63.3±121.1ng/mL。0.5mg/kg组50%（18/36）的样本和1mg/kg组39%（14/36）的样本中OND浓度低于定量下限（LLOQ）。6只犬（6/24，25%）在任何时候均未检测到OND。所有组在基线时的平均恶心评分相似且随时间下降。口服OND的生物利用度似乎较差。尽管血浆OND浓度较低，但恶心评分随时间有所改善。
