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COVID-19 与儿童多系统炎症综合征:肾脏有多脆弱?

COVID-19 and the multisystem inflammatory syndrome in children: how vulnerable are the kidneys?

机构信息

Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA; Acute Kidney Injury Program, Children's Mercy Kansas City, Kansas City, Missouri, USA; Division of Nephrology, Children's Mercy Kansas City, Kansas City, Missouri, USA.

Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA; Division of Nephrology, Children's Mercy Kansas City, Kansas City, Missouri, USA.

出版信息

Kidney Int. 2021 Jul;100(1):16-19. doi: 10.1016/j.kint.2021.03.043.

Abstract

When affected by coronavirus disease 2019 (COVID-19), most children have milder disease than what is experienced by adults. However, a subset of these children develops a multisystem inflammatory syndrome that can lead to shock and multiorgan failure. In the current issue, Basalely et al. characterize acute kidney injury in pediatric patients with acute COVID-19 and multisystem inflammatory syndrome. Despite the associated morbidity, this cohort provides evidence of kidney recovery in most affected children.

摘要

当感染 2019 冠状病毒病(COVID-19)时,大多数儿童的病情比成人轻。然而,这些儿童中有一部分会发展出一种多系统炎症综合征,可导致休克和多器官衰竭。在本期中,Basalely 等人描述了患有急性 COVID-19 和多系统炎症综合征的儿科患者的急性肾损伤。尽管存在相关发病率,但该队列为大多数受影响儿童的肾脏恢复提供了证据。

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本文引用的文献

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Outcomes Among Patients Hospitalized With COVID-19 and Acute Kidney Injury.COVID-19 合并急性肾损伤患者的住院结局。
Am J Kidney Dis. 2021 Feb;77(2):204-215.e1. doi: 10.1053/j.ajkd.2020.09.002. Epub 2020 Sep 19.
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Multisystem inflammatory syndrome in children: A systematic review.儿童多系统炎症综合征:一项系统评价。
EClinicalMedicine. 2020 Sep;26:100527. doi: 10.1016/j.eclinm.2020.100527. Epub 2020 Sep 4.
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Multisystem Inflammatory Syndrome in U.S. Children and Adolescents.美国儿童和青少年中的多系统炎症综合征。
N Engl J Med. 2020 Jul 23;383(4):334-346. doi: 10.1056/NEJMoa2021680. Epub 2020 Jun 29.

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