Talman W T, Florek G, Bullard D E
Department of Neurology, University of Iowa College of Medicine, Iowa City.
Arch Neurol. 1988 Sep;45(9):1037-40. doi: 10.1001/archneur.1988.00520330129022.
Although intracranial hypertension may cause autonomic disturbances, as well as alterations in the regulation of body temperature, an acute hyperthermic syndrome with autonomic disturbance as a consequence of hydrocephalus has not been described previously. Two subjects presented with such a syndrome, with each of several episodes of acute shunt failure and hydrocephalus. With correction of the hydrocephalus, the autonomic disturbances and fever immediately cleared. Observations from human and experimental studies suggest some potential mechanisms for the development of the syndrome. One of the subjects of this report was being treated with neuroleptics at the time of hospitalization; in him, and potentially in other similar patients, the syndrome could easily be confused with the neuroleptic malignant syndrome. The need for prompt appreciation of the correct diagnosis was emphasized by the rapid clearing of all neurological signs after correction of the shunt malfunction in both of these patients.
尽管颅内高压可能导致自主神经功能紊乱以及体温调节改变，但此前尚未有关于因脑积水导致以自主神经功能紊乱为后果的急性高热综合征的描述。两名患者出现了这样的综合征，伴有数次急性分流失败和脑积水发作。随着脑积水的纠正，自主神经功能紊乱和发热立即消退。来自人体和实验研究的观察结果提示了该综合征发生的一些潜在机制。本报告的一名患者在住院时正在接受抗精神病药物治疗；对他以及其他类似患者而言，该综合征很容易与抗精神病药物恶性综合征相混淆。这两名患者在分流故障纠正后所有神经体征迅速消退，这凸显了及时正确诊断的必要性。
