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Visualizing regulatory lymphocytic responses to predict neurological outcome after stroke.

作者信息

Xie Wanqing, Li Peiying

机构信息

Department of Anesthesiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

CNS Neurosci Ther. 2021 Aug;27(8):867-868. doi: 10.1111/cns.13698. Epub 2021 Jun 22.

DOI:10.1111/cns.13698
PMID:34156147
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8265945/
Abstract
摘要

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Pro: Regulatory T cells are protective in ischemic stroke.正方观点:调节性T细胞对缺血性中风具有保护作用。
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Regulatory T cells in ischemic stroke: helpful or hazardous?缺血性卒中中的调节性T细胞:有益还是有害?
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Con: Regulatory T cells are protective in ischemic stroke.反对观点:调节性T细胞在缺血性中风中具有保护作用。
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本文引用的文献

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Change and predictive ability of circulating immunoregulatory lymphocytes in long-term outcomes of acute ischemic stroke.急性缺血性卒中长期预后中循环免疫调节淋巴细胞的变化及预测能力
J Cereb Blood Flow Metab. 2021 Sep;41(9):2280-2294. doi: 10.1177/0271678X21995694. Epub 2021 Feb 27.
2
B cells migrate into remote brain areas and support neurogenesis and functional recovery after focal stroke in mice.B 细胞迁移到大脑的远处区域,并支持小鼠局灶性脑卒中后的神经发生和功能恢复。
Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4983-4993. doi: 10.1073/pnas.1913292117. Epub 2020 Feb 12.
3
Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery.脑调节性 T 细胞抑制星形胶质细胞增生并增强神经功能恢复。
Nature. 2019 Jan;565(7738):246-250. doi: 10.1038/s41586-018-0824-5. Epub 2019 Jan 2.
4
IL-2mAb reduces demyelination after focal cerebral ischemia by suppressing CD8 T cells.白细胞介素-2 单克隆抗体通过抑制 CD8 T 细胞减少局灶性脑缺血后的脱髓鞘。
CNS Neurosci Ther. 2019 Apr;25(4):532-543. doi: 10.1111/cns.13084. Epub 2018 Nov 15.
5
Cancer Exacerbates Ischemic Brain Injury Via Nrp1 (Neuropilin 1)-Mediated Accumulation of Regulatory T Cells Within the Tumor.癌症通过 Nrp1(神经纤毛蛋白 1)介导的肿瘤内调节性 T 细胞的积累加剧缺血性脑损伤。
Stroke. 2018 Nov;49(11):2733-2742. doi: 10.1161/STROKEAHA.118.021948.
6
Regulatory B cells in experimental stroke.实验性中风中的调节性 B 细胞。
Immunology. 2018 Jun;154(2):169-177. doi: 10.1111/imm.12887. Epub 2018 Feb 5.
7
Regulatory T cells ameliorate tissue plasminogen activator-induced brain haemorrhage after stroke.调节性T细胞可改善中风后组织型纤溶酶原激活剂诱导的脑出血。
Brain. 2017 Jul 1;140(7):1914-1931. doi: 10.1093/brain/awx111.
8
Dynamics of T cell responses after stroke.中风后T细胞反应的动力学
Curr Opin Pharmacol. 2016 Feb;26:26-32. doi: 10.1016/j.coph.2015.09.009. Epub 2015 Oct 8.
9
Adoptive regulatory T-cell therapy protects against cerebral ischemia.过继调节性 T 细胞疗法可预防脑缺血。
Ann Neurol. 2013 Sep;74(3):458-71. doi: 10.1002/ana.23815. Epub 2013 May 14.
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Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke.调节性T细胞是急性实验性中风中关键的脑保护免疫调节剂。
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