Romeo F, Iuele R, Grimaldi A, Gallippi G
Servizio di Anatomia ed Istologia Patologica, Ospedale Civile dell'Annunziata, Cosenza, Italy.
Basic Appl Histochem. 1988;32(2):255-61.
In non-specific and rheumatoid synovitis, the use of specific monoclonal antibodies against antigenic determinants of cells of the immune system showed that the characteristic changes of rheumatoid synovitis are located in the synovial internal layers. The monocytes were OKM1, OKM5, S100, OKDR positive, while the subintimal monocytes in non-specific synovitis were OKDR negative. We suggest that, in rheumatoid synovitis, the previously activated monocytes are transported by the bloodstream and pass through the so-called "sinovial barrier" to arrive in the subintimal layers ready to interact with T helper lymphocytes and initiate the immune response mechanisms responsible for lesions in rheumatoid synovitis.
在非特异性和类风湿性滑膜炎中，使用针对免疫系统细胞抗原决定簇的特异性单克隆抗体显示，类风湿性滑膜炎的特征性变化位于滑膜内层。单核细胞呈OKM1、OKM5、S100、OKDR阳性，而非特异性滑膜炎的内膜下单核细胞OKDR阴性。我们认为，在类风湿性滑膜炎中，先前被激活的单核细胞通过血流运输，穿过所谓的“滑膜屏障”，到达内膜下层，准备与辅助性T淋巴细胞相互作用，并启动负责类风湿性滑膜炎病变的免疫反应机制。
