Ziff M
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-9030.
Int J Tissue React. 1993;15(3):135-7.
The rheumatoid mononuclear cell infiltrate has a number of features of a cellular immune response. In the latter, the immunological specificity of the lymphocytic infiltrate is largely independent of the inciting antigen. Extensive investigation of the possible clonal or oligoclonal dominance of T-cell populations of the rheumatoid synovial infiltrate has demonstrated either no clonality or a dominance of T-cell populations with T-cell receptor V regions which have varied from patient group to patient group and, frequently, from patient to patient within a given group. These findings suggest that the basis for the mobilization of the synovial T-cell population is the activation state of the circulating T cells, not their immunological specificity, which makes them eligible for endothelial binding and transmigration. The specificity of the activated T cells of the circulating T-cell pool appears to be determined by the immunological history of the host.
类风湿性单核细胞浸润具有细胞免疫反应的若干特征。在细胞免疫反应中，淋巴细胞浸润的免疫特异性很大程度上独立于激发抗原。对类风湿性滑膜浸润中T细胞群体可能的克隆性或寡克隆优势进行的广泛研究表明，要么不存在克隆性，要么T细胞群体以T细胞受体V区占优势，这些区域在不同患者组之间各不相同，并且在给定组内的患者之间也常常不同。这些发现表明，滑膜T细胞群体动员的基础是循环T细胞的激活状态，而非其免疫特异性，这使得它们能够与内皮细胞结合并迁移。循环T细胞库中活化T细胞的特异性似乎由宿主的免疫史决定。
