15-氢过氧二十碳四烯酸及相关类花生酸对人白细胞5-脂氧合酶的抑制作用。
Inhibition of human leukocyte 5-lipoxygenase by 15-HPETE and related eicosanoids.
作者信息
Cashman J R, Lambert C, Sigal E
机构信息
Department of Pharmaceutical Chemistry and Liver Center, University of California, San Francisco 94115.
出版信息
Biochem Biophys Res Commun. 1988 Aug 30;155(1):38-44. doi: 10.1016/s0006-291x(88)81046-5.
The inhibition of human leukocyte 5-lipoxygenase by 15-hydroperoxyeicosatetraenoic acid and its chemical or enzymatic rearrangement products was investigated. 15-Hydroperoxyeicosatetraenoic acid was the most potent inhibitor tested. The inhibition was found to be time dependent and is not due to chemical or enzymatic decomposition products nor metabolism of 15-hydroperoxyeicosatetraenoic acid to 5,15-dihydroperoxyeicosatetraenoic acid.
研究了15-氢过氧二十碳四烯酸及其化学或酶促重排产物对人白细胞5-脂氧合酶的抑制作用。15-氢过氧二十碳四烯酸是所测试的最有效的抑制剂。发现这种抑制作用具有时间依赖性，且不是由于化学或酶促分解产物，也不是由于15-氢过氧二十碳四烯酸代谢为5,15-二氢过氧二十碳四烯酸所致。
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