Department of Medicine, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
Department of Nursing, Mbarara University of Science and Technology, Mbarara, Uganda.
PLoS One. 2021 Jun 22;16(6):e0251662. doi: 10.1371/journal.pone.0251662. eCollection 2021.
INTRODUCTION: Stroke burden is rapidly increasing globally. Modifiable risk factors offer an opportunity to intervene, and targeting hypertension is a key actionable target for stroke risk reduction in sub-Saharan Africa. This 3-site planned randomized controlled trial builds on promising preliminary data. METHODS: A total of 246 Ugandan adults will be recruited randomized to experimental intervention vs. enhanced treatment control. Intervention participants will receive six weekly group-format stroke risk reduction self-management training sessions, and the controls will receive information on cardiovascular risk. The primary study outcome is systolic B.P. measured at baseline, 13-week, 24 weeks (6 months). Secondary outcomes include other biological and behavioral stroke risk factors. DISCUSSION: The curriculum-guided self-management TargetEd MAnageMent Intervention (TEAM) program is anticipated to reduce the stroke burden in Uganda. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT04685408, registered on 28 December 2020.
简介：全球范围内，中风负担正在迅速增加。可改变的风险因素为干预提供了机会，而针对高血压是减少撒哈拉以南非洲地区中风风险的一个关键可行目标。这项三地点计划随机对照试验是基于有希望的初步数据。
方法：总共将招募 246 名乌干达成年人，随机分为实验组和强化治疗对照组。实验组将接受六次每周一次的团体形式的中风风险降低自我管理培训课程，对照组将获得心血管风险信息。主要研究结果是基线、13 周、24 周（6 个月）时测量的收缩压。次要结果包括其他生物和行为中风风险因素。
讨论：预计课程指导的自我管理靶向管理干预（TEAM）方案将减少乌干达的中风负担。
试验注册：ClinicalTrials.gov 标识符：NCT04685408，于 2020 年 12 月 28 日注册。
Cochrane Database Syst Rev. 2022-2-1
BMC Res Notes. 2015-12-26
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