队列研究的荟萃分析：创伤性脑损伤与阿尔茨海默病风险。

A meta-analysis of cohort studies: Traumatic brain injury and risk of Alzheimer's Disease.

机构信息

Fuzhou Medical College of Nanchang University, Fuzhou, China.

Jiangxi Cancer Hospital, Nanchang, China.

出版信息

PLoS One. 2021 Jun 22;16(6):e0253206. doi: 10.1371/journal.pone.0253206. eCollection 2021.

DOI:10.1371/journal.pone.0253206

PMID:34157045

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8219123/

Abstract

INTRODUCTION

Recently, some epidemiological studies have reported that cognitive disorders in elderly people is accelerated with traumatic brain injury. But the causal relationship between traumatic brain injury and AD is still an area of controversy.

AIMS

Our review was conducted to estimate the relation between traumatic brain injury and risk of AD.

METHODS

All longitudinal population-based studies comparing incidence of AD between subjects with and without traumatic brain injury from their inception to September 2020 were searched in The Cochrane Library, PubMed, Medline, Embase, Web of Science without restriction of language. The meta-analysis was conducted using Stata software.

RESULTS

A total of 17 studies involving 4289,548 individuals were included. After pooling these 17 studies, subjects with traumatic brain injury had significant higher incidence of AD than those without traumatic brain injury (RR: 1.17, 95% CI: 1.05-1.29). When considering the severity of traumatic brain injury, this elevated risk of AD was still significant comparing subjects with moderate and severe traumatic brain injury and those with no traumatic brain injury (RR: 1.30, 95% CI: 1.01-1.59).

CONCLUSION

Traumatic brain injury, especially moderate and severe traumatic brain injury may be associated with increased risk of AD.

摘要

简介

最近，一些流行病学研究报告称，老年人的认知障碍随着创伤性脑损伤而加速。但是创伤性脑损伤和 AD 之间的因果关系仍然存在争议。

目的

我们的综述旨在评估创伤性脑损伤与 AD 风险之间的关系。

方法

我们在 Cochrane Library、PubMed、Medline、Embase、Web of Science 中检索了所有从成立到 2020 年 9 月比较创伤性脑损伤患者和无创伤性脑损伤患者 AD 发生率的基于人群的纵向研究，语言不限。使用 Stata 软件进行荟萃分析。

结果

共纳入 17 项研究，涉及 4289548 人。对这 17 项研究进行汇总后，创伤性脑损伤患者的 AD 发生率明显高于无创伤性脑损伤患者（RR：1.17，95%CI：1.05-1.29）。当考虑创伤性脑损伤的严重程度时，与无创伤性脑损伤相比，中重度创伤性脑损伤患者发生 AD 的风险仍显著升高（RR：1.30，95%CI：1.01-1.59）。