Faculty of Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia.
V. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, 117997 Moscow, Russia.
Biochim Biophys Acta Rev Cancer. 2021 Aug;1876(1):188584. doi: 10.1016/j.bbcan.2021.188584. Epub 2021 Jun 19.
An emerging role of long non-coding RNAs (lncRNAs) in tumor progression has been revealed in the last decade. Through interactions with nucleic acids and proteins, lncRNAs could act as enhancers, scaffolds or decoys for a number of oncoproteins and tumor suppressors. The aberrant lncRNA expression or mutations are often associated with changes in a variety of cellular processes, including proliferation, stress response and cell death. Here, we will focus on the tumor-associated lncRNAs in ovarian cancer according to their contribution to cancer hallmarks, such as intense proliferation, cell death resistance, altered energy metabolism, invasion and metastasis, and immune evasion. Moreover, the potential clinical implications of lncRNAs and their significance for the diagnosis, prognosis and therapy of ovarian cancer will be discussed.
在过去的十年中，长链非编码 RNA（lncRNA）在肿瘤进展中的新兴作用已经被揭示。通过与核酸和蛋白质相互作用，lncRNA 可以作为许多癌蛋白和肿瘤抑制因子的增强子、支架或诱饵。异常的 lncRNA 表达或突变通常与多种细胞过程的变化相关，包括增殖、应激反应和细胞死亡。在这里，我们将根据它们对癌症特征的贡献，重点讨论卵巢癌中的肿瘤相关 lncRNA，如强烈的增殖、抵抗细胞死亡、改变的能量代谢、侵袭和转移以及免疫逃逸。此外，还将讨论 lncRNA 的潜在临床意义及其对卵巢癌的诊断、预后和治疗的意义。
