Department of Pharmaceutical Sciences and Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN, USA.
Department of Pharmaceutical Sciences and Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN, USA.
Drug Discov Today. 2018 Sep;23(9):1635-1643. doi: 10.1016/j.drudis.2018.04.010. Epub 2018 Apr 23.
Long noncoding RNAs (lncRNAs) are a class of noncoding RNA, involved in regulation of diverse physiological and pathological processes. Ovarian cancer is the leading cause of death among all gynecological malignancies in the world and its underlying mechanism is still unclear. LncRNAs exhibit multiple biological functions in various stages of ovarian cancer development. We will discuss and summarize the new and important lncRNAs and their involvement in disease, which might represent promising therapeutic targets. Therapeutic intervention based on silencing or functional inhibition of target lncRNAs will be beneficial for ovarian cancer patients.
长链非编码 RNA(lncRNAs)是一类非编码 RNA,参与多种生理和病理过程的调节。卵巢癌是全球妇科恶性肿瘤死亡的主要原因,其发病机制尚不清楚。lncRNAs 在卵巢癌发展的各个阶段表现出多种生物学功能。我们将讨论和总结新的和重要的 lncRNAs 及其在疾病中的作用,这些可能代表有前途的治疗靶点。基于沉默或功能性抑制靶 lncRNAs 的治疗干预将有利于卵巢癌患者。