Clinical Department, Humankind, Durham, UK.
Aston Pharmacy School, Aston University, Birmingham, UK.
BMJ Open. 2021 Jun 22;11(6):e047283. doi: 10.1136/bmjopen-2020-047283.
There is a growing concern about the misuse of over the counter (OTC) and prescription only medication (POM) because of the impact on physical and mental health, drug interactions, overdoses and drug-related deaths. These medicines include opioid analgesics, anxiolytics such as pregabalin and diazepam and antidepressants. This protocol outlines how a systematic review will be undertaken (during June 2021), which aims to examine the literature on the pattern of OTC and POM misuse among adults who are accessing substance misuse treatment services. It will include the types of medication being taken, prevalence and demographic characteristics of people who access treatment services.
An electronic search will be conducted on the Cochrane, OVID Medline, Pubmed, Scopus and Web of Science databases as well as grey literature. Two independent reviewers will conduct the initial title and abstract screenings, using predetermined criteria for inclusion and exclusion. If selected for inclusion, full-text data extraction will be conducted using a pilot-tested data extraction form. A third reviewer will resolve disagreements if consensus cannot be reached. Quality and risk of bias assessment will be conducted for all included studies. A qualitative synthesis and summary of the data will be provided. If possible, a meta-analysis with heterogeneity calculation will be conducted; otherwise, Synthesis Without Meta-analysis will be undertaken for quantitative data. The reporting of this protocol follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.
Ethical approval is not required. Findings will be peer reviewed, published and shared verbally, electronically and in print, with interested clinicians and policymakers.
CRD42020135216.
由于对身心健康、药物相互作用、过量用药和与药物相关的死亡的影响，人们越来越关注非处方 (OTC) 和仅限处方 (POM) 药物的滥用问题。这些药物包括阿片类镇痛药、普瑞巴林和地西泮等苯二氮䓬类药物以及抗抑郁药。本方案概述了如何进行系统评价（于 2021 年 6 月进行），旨在研究接受药物滥用治疗服务的成年人中 OTC 和 POM 滥用模式的文献。它将包括正在服用的药物类型、接受治疗服务的人群的流行率和人口统计学特征。
将在 Cochrane、OVID Medline、Pubmed、Scopus 和 Web of Science 数据库以及灰色文献中进行电子检索。两名独立评审员将使用预定的纳入和排除标准进行初始标题和摘要筛选。如果入选，将使用经过试点测试的数据提取表格进行全文数据提取。如果无法达成共识，将由第三名评审员解决分歧。将对所有纳入的研究进行质量和偏倚风险评估。将提供数据的定性综合和总结。如果可能，将进行具有异质性计算的荟萃分析；否则，将对定量数据进行无荟萃分析的综合。本方案的报告遵循系统评价和荟萃分析的首选报告项目。
不需要伦理批准。研究结果将经过同行评审，以口头、电子和印刷形式发表和分享，与有兴趣的临床医生和政策制定者分享。
PROSPERO 注册号：CRD42020135216。
