阿片类物质使用障碍患者中电子烟使用与健康结局之间的关联：一项系统评价方案

Association between vaping and health outcomes in patients with opioid use disorder: a systematic review protocol.

作者信息

Sanger Nitika, D'Elia Alessia, Sanger Stephanie, Rosic Tea, Samaan M Constantine, Kapczinski Flávio, de Souza Russell J, Thabane Lehana, Samaan Zainab

机构信息

Medical Science Program, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada.

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.

出版信息

BMJ Open. 2021 Jan 19;11(1):e040349. doi: 10.1136/bmjopen-2020-040349.

DOI:10.1136/bmjopen-2020-040349

PMID:33468604

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7817795/

Abstract

INTRODUCTION

Vaping behaviour has increased in popularity and is particularly important to examine how it effects health outcomes in vulnerable populations, including those with opioid use disorder (OUD). With polysubstance use including cigarette and cannabis use being highly prevalent in the OUD population and cannabis/nicotine increasingly being consumed by vaping, vaping may have an important contribution to health outcomes in these individuals. The primary objective of this review is to systematically assess the literature related to patients with OUD and the effects vaping has shown on their physical and mental health.

METHOD AND ANALYSIS

A systematic search of databases including MEDLINE, Embase, PsycINFO, Web of Science, Cumulative Index to Nursing and Allied Health Literature, Cochrane Library, Cochrane Clinical Trials Registry, the National Institutes for Health Clinical Trials Registry and the WHO International Clinical Trials Registry Platform from inception to 31 December 2020 will be conducted. Identified citations will be screened by two reviewers to determine eligibility at the title and abstract level, and then at the full text and data extraction phases. Any disagreements in inclusion will be resolved through unblinded discussion by these reviewers, with any remaining disagreements being resolved by a third reviewer. Data collection from eligible studies will be conducted according to the data extraction form tested prior to abstraction. Included studies will be examined for quality and bias and will be meta-analysed where applicable. This protocol is reported in keeping with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guidelines.

ETHICS AND DISSEMINATION

The results for this review will be disseminated through publications in peer-reviewed journals, posters and presentations at scientific conferences. Additionally, we are collaborating with the Canadian Addiction Treatment Centre clinics to help disseminate the findings for this review. As this is a systematic review, no ethics approval is needed.

REVIEW REGISTRATION NUMBER

CRD42020178441.

摘要

引言

电子烟使用行为日益普遍，研究其对包括阿片类物质使用障碍（OUD）患者在内的弱势群体健康结果的影响尤为重要。在OUD人群中，包括吸烟和吸食大麻在内的多物质使用非常普遍，并且大麻/尼古丁越来越多地通过电子烟吸食，电子烟可能对这些人的健康结果产生重要影响。本综述的主要目的是系统评估与OUD患者相关的文献以及电子烟对其身心健康的影响。

方法与分析

将对包括MEDLINE、Embase、PsycINFO、科学网、护理及相关健康文献累积索引、考克兰图书馆、考克兰临床试验注册库、美国国立卫生研究院临床试验注册库和世界卫生组织国际临床试验注册平台在内的数据库进行系统检索，检索时间从数据库建立至2020年12月31日。两名评审员将对检索到的文献进行筛选，以确定在标题和摘要层面以及全文和数据提取阶段的 eligibility。纳入方面的任何分歧将通过这些评审员的非盲讨论解决，任何剩余分歧将由第三位评审员解决。将根据抽象前测试的数据提取表从符合条件的研究中收集数据。将对纳入的研究进行质量和偏倚检查，并在适用时进行荟萃分析。本方案按照系统评价与荟萃分析方案的首选报告项目指南进行报告。