Nanobiosensorics Laboratory, ELKH EK MFA, Budapest, Hungary.
Division of Medical Image Computing (MIC), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Sci Rep. 2021 Jun 22;11(1):13091. doi: 10.1038/s41598-021-92327-4.
Numerical simulations and analytical calculations are performed to support the design of grating-coupled planar optical waveguides for biological sensing. Near cut-off and far from cut-off modes are investigated, and their characteristics and suitability for sensing are compared. The numerical simulations reveal the high sensitivity of the guided mode intensity near the cut-off wavelength for any refractive index change along the waveguide. Consequently, it is sufficient to monitor the intensity change of the near cut-off sensing mode, which leads to a simpler sensor design compared to those setups where the resonant wavelength shift of the guided mode is monitored with high precision. The operating wavelength and the sensitivity of the proposed device can be tuned by varying the geometrical parameters of the corrugated waveguide. These results may lead to the development of highly sensitive integrated sensors, which have a simple design and therefore are cost-effective for a wide range of applications. These numerical findings are supported with experimental results, where the cut-off sensing mode was identified.
进行数值模拟和分析计算，以支持用于生物传感的光栅耦合平面光波导的设计。研究了近截止和远截止模式，并比较了它们的特性和用于传感的适用性。数值模拟揭示了在沿波导的任何折射率变化下，截止波长附近导模强度的高灵敏度。因此，只需监测近截止传感模式的强度变化，与那些需要高精度监测导模共振波长移动的传感器设计相比，这导致了更简单的传感器设计。通过改变波纹波导的几何参数，可以调整所提出的器件的工作波长和灵敏度。这些结果可能会导致开发出高度灵敏的集成传感器，这些传感器具有简单的设计，因此对于广泛的应用具有成本效益。这些数值结果得到了实验结果的支持，其中识别出了截止传感模式。
