放射性治疗联合化疗的大鼠模型中的呼吸-吞咽协调。
Respiratory-swallow coordination in a rat model of chemoradiation.
机构信息
Department of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Department of Surgery-Otolaryngology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
出版信息
Head Neck. 2021 Oct;43(10):2954-2966. doi: 10.1002/hed.26782. Epub 2021 Jun 23.
BACKGROUND
Chemoradiation treatment (CRT) for head and neck cancer (HNC) is associated with postswallow inhale events that elevate the risk of penetration/aspiration. The purpose of this study was to assess the validity of a rat model for investigating the effect of CRT on respiratory-swallow coordination.
METHODS
Videofluoroscopic swallow study was performed on 10 Sprague-Dawley rats 3 months post-CRT (3 mg/kg Cisplatin, 10 fractions of 4.5 Gy/day radiotherapy to tongue base), and 10 naïve controls. We examined the effect of CRT on swallow apnea duration, diaphragm movement, and bolus kinematics.
RESULTS
CRT rats had a significant increase in postswallow inhale (p = 0.008), which was associated with significantly longer swallow apnea durations, lower diaphragm displacement at swallow onset, and faster pharyngoesophageal bolus speed.
CONCLUSION
The rat CRT model is valid for the study of respiratory-swallow coordination due to the consistency of findings in this study with those reported in clinical CRT studies in HNC.
背景
头颈部癌症（HNC）的放化疗（CRT）与吞咽后吸入事件有关，这些事件会增加渗透/吸入的风险。本研究的目的是评估一种用于研究 CRT 对呼吸-吞咽协调性影响的大鼠模型的有效性。
方法
对 10 只接受 CRT（3mg/kg 顺铂，舌基 10 次 4.5Gy/天放疗）后的 3 个月龄 Sprague-Dawley 大鼠和 10 只未处理的对照大鼠进行荧光透视吞咽研究。我们研究了 CRT 对吞咽暂停持续时间、膈肌运动和食团运动学的影响。
结果
CRT 大鼠在吞咽后吸入（p=0.008）方面有显著增加，这与吞咽暂停持续时间明显延长、吞咽起始时膈肌位移降低以及咽食管食团速度加快有关。
结论
由于该研究结果与 HNC 临床 CRT 研究中的结果一致，因此大鼠 CRT 模型适用于呼吸-吞咽协调性的研究。
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