Takeuchi M, Nagura H, Kaneda T
Department of Oral Surgery, Nagoya University School of Medicine, Japan.
Blood. 1988 Sep;72(3):850-4.
A peroxidase-labeled antibody technique revealed von Willebrand factor antigen (vWF:Ag) in rough endoplasmic reticulum (rER), the perinuclear region, and the cytoplasmic vesicles of capillary endothelial cells in oral mucosa. After administration of epinephrine or 1-deamino-8-D-arginine vasopressin (DDAVP), the localization of vWF:Ag was shown to have changed to the basement membrane and the surrounding interstitium. This change of vWF:Ag localization induced by epinephrine and DDAVP may play a role in the adhesion of platelets to subendothelium following endothelial injury during surgery and may be an unknown hemostatic effect of these drugs.
过氧化物酶标记抗体技术显示，口腔黏膜毛细血管内皮细胞的粗面内质网（rER）、核周区域和胞质小泡中有血管性血友病因子抗原（vWF:Ag）。给予肾上腺素或1-去氨基-8-D-精氨酸加压素（DDAVP）后，vWF:Ag的定位显示已改变至基底膜和周围间质。肾上腺素和DDAVP诱导的vWF:Ag定位变化可能在手术期间内皮损伤后血小板与内皮下层的黏附中起作用，并且可能是这些药物未知的止血作用。
