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锌对脊髓损伤的保护作用。

Protective Effects of Zinc on Spinal Cord Injury.

机构信息

Department of Orthopedic, First Affiliated Hospital of Jinzhou Medical University, Jinzhou Medical University, Jinzhou, 121001, People's Republic of China.

出版信息

J Mol Neurosci. 2021 Dec;71(12):2433-2440. doi: 10.1007/s12031-021-01859-x. Epub 2021 Jun 23.

Abstract

Spinal cord injury is a serious disease of the central nervous system, but there is no effective treatment. And zinc is an essential nutrient for human body and participates in many physiological processes, such as immune response, homeostasis, oxidative stress, cell cycle progression, DNA replication, DNA damage repair, apoptosis, and aging. This article mainly summarizes that zinc could predict the prognosis and treat the spinal cord injury. Especially, zinc could help to inhibit inflammation, regulate autophagy, and reduce oxidative stress. However, excessive zinc will damage neurons.

摘要

脊髓损伤是一种严重的中枢神经系统疾病,但目前尚无有效的治疗方法。锌是人体必需的营养物质,参与许多生理过程,如免疫反应、内稳态、氧化应激、细胞周期进展、DNA 复制、DNA 损伤修复、细胞凋亡和衰老。本文主要综述了锌对脊髓损伤的预后判断和治疗作用。锌可以通过抑制炎症、调节自噬和减轻氧化应激来发挥作用。但是,过量的锌会损伤神经元。

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