维生素在脊髓损伤中的作用：机制与益处。
The Role of Vitamins in Spinal Cord Injury: Mechanisms and Benefits.
机构信息
Neurobiology Research Center Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Neuroscience Research Center Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Oxid Med Cell Longev. 2024 Jun 20;2024:4293391. doi: 10.1155/2024/4293391. eCollection 2024.
Abstract
Spinal cord injury (SCI) is a common neurological disease worldwide, often resulting in a substantial decrease in quality of life, disability, and in severe cases, even death. Unfortunately, there is currently no effective treatment for this disease. Nevertheless, current basic and clinical evidence suggests that vitamins, with their antioxidant properties and biological functions, may play a valuable role in improving the quality of life for individuals with SCI. They can promote overall health and facilitate the healing process. In this review, we discuss the mechanisms and therapeutic potential of vitamins in the treatment of SCI.
摘要
脊髓损伤（SCI）是一种常见的全球神经系统疾病，通常导致生活质量显著下降、残疾，在严重的情况下甚至死亡。不幸的是，目前对此疾病没有有效的治疗方法。然而，当前的基础和临床证据表明，维生素具有抗氧化特性和生物学功能，可能在改善 SCI 患者的生活质量方面发挥重要作用。它们可以促进整体健康并促进愈合过程。在这篇综述中，我们讨论了维生素在 SCI 治疗中的作用机制和治疗潜力。
相似文献
1
The Role of Vitamins in Spinal Cord Injury: Mechanisms and Benefits.维生素在脊髓损伤中的作用：机制与益处。
Oxid Med Cell Longev. 2024 Jun 20;2024:4293391. doi: 10.1155/2024/4293391. eCollection 2024.
2
Bioactive role of vitamins as a key modulator of oxidative stress, cellular damage and comorbidities associated with spinal cord injury (SCI).维生素作为氧化应激、细胞损伤和与脊髓损伤（SCI）相关的合并症的关键调节剂的生物活性作用。
Nutr Neurosci. 2023 Nov;26(11):1120-1137. doi: 10.1080/1028415X.2022.2133842. Epub 2022 Dec 20.
3
Oxidative stress in spinal cord injury and antioxidant-based intervention.脊髓损伤中的氧化应激和基于抗氧化剂的干预。
Spinal Cord. 2012 Apr;50(4):264-74. doi: 10.1038/sc.2011.111. Epub 2011 Oct 11.
4
Neurological recovery and antioxidant effects of curcumin for spinal cord injury in the rat: a network meta-analysis and systematic review.姜黄素对大鼠脊髓损伤的神经恢复及抗氧化作用：一项网状Meta分析与系统评价
J Neurotrauma. 2015 Mar 15;32(6):381-91. doi: 10.1089/neu.2014.3520. Epub 2015 Jan 9.
5
Resveratrol can improve spinal cord injury by activating Nrf2/HO-1 signaling pathway.白藜芦醇可以通过激活 Nrf2/HO-1 信号通路来改善脊髓损伤。
Ann Anat. 2024 Jan;251:152180. doi: 10.1016/j.aanat.2023.152180. Epub 2023 Oct 23.
6
Nanoparticles Exacerbate Both Ubiquitin and Heat Shock Protein Expressions in Spinal Cord Injury: Neuroprotective Effects of the Proteasome Inhibitor Carfilzomib and the Antioxidant Compound H-290/51.纳米颗粒加剧脊髓损伤中的泛素和热休克蛋白表达：蛋白酶体抑制剂卡非佐米和抗氧化剂化合物 H-290/51 的神经保护作用。
Mol Neurobiol. 2015 Oct;52(2):882-98. doi: 10.1007/s12035-015-9297-9. Epub 2015 Jul 1.
7
The neuroprotective role of morroniside against spinal cord injury in female rats.莫诺苷对雌性大鼠脊髓损伤的神经保护作用。
Neurochem Int. 2021 Sep;148:105105. doi: 10.1016/j.neuint.2021.105105. Epub 2021 Jun 17.
8
The Importance of Natural Antioxidants in the Treatment of Spinal Cord Injury in Animal Models: An Overview.天然抗氧化剂在动物模型脊髓损伤治疗中的重要性：综述。
Oxid Med Cell Longev. 2019 Nov 12;2019:3642491. doi: 10.1155/2019/3642491. eCollection 2019.
9
Therapeutic potential of flavonoids in spinal cord injury.黄酮类化合物在脊髓损伤中的治疗潜力。
Rev Neurosci. 2017 Jan 1;28(1):87-101. doi: 10.1515/revneuro-2016-0053.
10
Antioxidant therapies for acute spinal cord injury.抗氧化疗法治疗急性脊髓损伤。
Neurotherapeutics. 2011 Apr;8(2):152-67. doi: 10.1007/s13311-011-0026-4.
引用本文的文献
1
Exploring the Analgesic Potential of L-Lysine: Molecular Mechanisms, Preclinical Evidence, and Implications for Pharmaceutical Pain Therapy.探索L-赖氨酸的镇痛潜力：分子机制、临床前证据及对药物性疼痛治疗的意义。
Pharmaceutics. 2025 May 19;17(5):666. doi: 10.3390/pharmaceutics17050666.
2
Human dental pulp stem cells for spinal cord injury.用于脊髓损伤的人牙髓干细胞。
Stem Cell Res Ther. 2025 Mar 7;16(1):123. doi: 10.1186/s13287-025-04244-2.
本文引用的文献
1
Oxidative stress following spinal cord injury: From molecular mechanisms to therapeutic targets.脊髓损伤后的氧化应激：从分子机制到治疗靶点。
J Neurosci Res. 2023 Oct;101(10):1538-1554. doi: 10.1002/jnr.25221. Epub 2023 Jun 5.
2
Impact of vitamin D on the prognosis after spinal cord injury: A systematic review.维生素D对脊髓损伤后预后的影响：一项系统评价。
Front Nutr. 2023 Feb 14;10:920998. doi: 10.3389/fnut.2023.920998. eCollection 2023.
3
Use of the Rehabilitation Treatment Specification System (RTSS) in the management of nitrous oxide (NO)-induced spinal cord injury.康复治疗规范系统（RTSS）在一氧化二氮（NO）诱导的脊髓损伤管理中的应用。
BMJ Case Rep. 2023 Feb 7;16(2):e252529. doi: 10.1136/bcr-2022-252529.
4
Subacute Combined Degeneration of the Spinal Cord: A Consequence of Recreational Nitrous Oxide Use.脊髓亚急性联合变性：娱乐性使用一氧化二氮的后果。
Cureus. 2022 Nov 27;14(11):e31936. doi: 10.7759/cureus.31936. eCollection 2022 Nov.
5
Therapy of spinal cord injury by folic acid polyethylene glycol amine-modified zeolitic imidazole framework-8 nanoparticles targeted activated M/Ms.叶酸聚乙二醇胺修饰的沸石咪唑骨架-8纳米颗粒靶向活化的巨噬细胞/小胶质细胞治疗脊髓损伤
Front Bioeng Biotechnol. 2022 Sep 15;10:959324. doi: 10.3389/fbioe.2022.959324. eCollection 2022.
6
Zinc Promotes Spinal Cord Injury Recovery by Blocking the Activation of NLRP3 Inflammasome Through SIRT3-Mediated Autophagy.锌通过SIRT3介导的自噬阻断NLRP3炎性小体的激活来促进脊髓损伤的恢复。
Neurochem Res. 2023 Feb;48(2):435-446. doi: 10.1007/s11064-022-03762-2. Epub 2022 Sep 24.
7
Vitamin D Promotes Remyelination by Suppressing c-Myc and Inducing Oligodendrocyte Precursor Cell Differentiation after Traumatic Spinal Cord Injury.维生素 D 通过抑制 c-Myc 和诱导少突胶质前体细胞分化促进创伤性脊髓损伤后的髓鞘再生。
Int J Biol Sci. 2022 Aug 29;18(14):5391-5404. doi: 10.7150/ijbs.73673. eCollection 2022.
8
The Dark Side of Iron: The Relationship between Iron, Inflammation and Gut Microbiota in Selected Diseases Associated with Iron Deficiency Anaemia-A Narrative Review.铁的阴暗面：缺铁性贫血相关疾病中铁、炎症和肠道微生物群的关系——综述。
Nutrients. 2022 Aug 24;14(17):3478. doi: 10.3390/nu14173478.
9
Vitamin D Toxicity from an Unusual and Unexpected Source: A Report of 2 Cases.维生素 D 毒性的不常见且意想不到的来源：2 例报告。
Horm Res Paediatr. 2023;96(3):332-340. doi: 10.1159/000526755. Epub 2022 Aug 26.
10
Omega-3 fatty acids in the treatment of spinal cord injury: untapped potential for therapeutic intervention?ω-3 脂肪酸在脊髓损伤治疗中的作用：治疗干预的未开发潜力？
Mol Biol Rep. 2022 Nov;49(11):10797-10809. doi: 10.1007/s11033-022-07762-x. Epub 2022 Jul 18.
Zotero 插件