Garcia Hugo, Teuma Cécile, Languille Eva
"Service de néphrologie, groupe hospitalier La Pitié-Salpêtrière-Charles-Foix, Paris, France".
"Service de néphrologie, dialyse et transplantation, hôpital Foch, Suresnes, France".
Rev Prat. 2021 Feb;71(2):193-197.
"Renal toxicity of antineoplasic agents Renal toxicity of antineoplasic agents is a common complication faced by oncologists and nephrologists whose incidence depends on therapeutic classes used and patient's comorbidities. Nephrotoxicity is variable, according to mecanisms, chronology and potential reversibility. Besides acute kidney injury and/or chronic kidney disease, clinical features include several urinary abnormalities (mainly proteinuria). The onset of renal toxicity may directly compromise vital prognosis and may lead to the interruption of medications affecting cancer-specific mortality. Nephrotoxicity prevention (when feasible) and rapid diagnosis are essential to optimize cancer-patient medical care."
抗肿瘤药物的肾毒性 抗肿瘤药物的肾毒性是肿瘤学家和肾病学家面临的常见并发症，其发生率取决于所使用的治疗类别和患者的合并症。根据作用机制、时间顺序和潜在可逆性，肾毒性各不相同。除急性肾损伤和/或慢性肾脏病外，临床特征还包括几种尿液异常（主要是蛋白尿）。肾毒性的发生可能直接危及重要预后，并可能导致影响癌症特异性死亡率的药物中断。肾毒性预防（可行时）和快速诊断对于优化癌症患者的医疗护理至关重要。
