DeFelipe J, Conti F, Van Eyck S L, Manzoni T
Institute of Human Physiology, University of Ancona, Italy.
Brain Res. 1988 Jul 5;455(1):162-5. doi: 10.1016/0006-8993(88)90127-8.
Electron microscopic examination of sections immunocytochemically processed with an anti-glutamate serum reveals that many asymmetric synapses in the cat neocortex contain elevated levels of immunodetectable glutamate. These labelled axon terminals are likely to use glutamate as neurotransmitter. Axon terminals forming symmetric contacts were never labelled. Since glutamate is known to exert potent excitatory effects on neocortical neurons, the present finding gives immunocytochemical evidence that asymmetric synapses are excitatory.
用抗谷氨酸血清进行免疫细胞化学处理后的切片的电子显微镜检查显示，猫新皮质中的许多不对称突触含有免疫可检测到的高水平谷氨酸。这些标记的轴突终末可能以谷氨酸作为神经递质。形成对称接触的轴突终末从未被标记。由于已知谷氨酸对新皮质神经元具有强大的兴奋作用，目前的发现提供了免疫细胞化学证据，表明不对称突触是兴奋性的。
