Vandevelde M, Kristensen B
Acta Neuropathol. 1977 Nov 28;40(3):233-6. doi: 10.1007/BF00691959.
The distribution of canine distemper virus in the central nervous system was examined in 11 dogs with demyelinating encephalitis by the direct fluorescent antibody technique on paraffin sections of brain and spinal cord. In the grey matter there was a good correlation between the presence and severity of lesions and presence and amount of viral antigen. Large concentrations of virus were found in neurons and their processes. In most demyelinating lesions only small amounts of viral antigen were found, mostly located in astrocytes. The potential importance of the role of the astrocyte in demyelination in canine distemper virus infection is stressed.
采用直接荧光抗体技术，对11只患有脱髓鞘性脑炎的犬脑和脊髓石蜡切片进行检测，以研究犬瘟热病毒在中枢神经系统中的分布情况。在灰质中，病变的存在与严重程度和病毒抗原的存在与数量之间存在良好的相关性。在神经元及其突起中发现了大量病毒。在大多数脱髓鞘病变中，仅发现少量病毒抗原，主要位于星形胶质细胞中。强调了星形胶质细胞在犬瘟热病毒感染脱髓鞘过程中所起作用的潜在重要性。
