Sawicki W, Choroszewska A, Bem W, Strojny P
Department of Histology and Embryology, Warsaw Medical School, Poland.
Cell Tissue Res. 1988 Jul;253(1):241-4. doi: 10.1007/BF00221759.
The number of intraepithelial lymphocytes (IEL) in the luminal and glandular epithelium of the uterus of virgin rats was analysed in diestrus, proestrus and estrus, and in nulliparous rats on days 5, 7 and 9 of pregnancy. IEL number was calculated either with respect to the number of epithelial cells or to the length of epithelium section. It was found that in diestrus, the number of IEL was, on average, 3.7 per 100 luminal epithelial cells or 6.7 per 1 mm of epithelium section, whereas in proestrus, it decreased to 0.9 and 1.2 IEL, respectively. On day 5 of pregnancy (before implantation) the number of IEL decreased further to 0.45 per 100 luminal epithelial cells or 0.9 per 1 mm of epithelium. On days 7 and 9 of pregnancy, IEL number further decreased in implantation sites, whereas in interimplantation sites it remained at the level calculated for day 5 of pregnancy. The population of uterine IEL consisted of small (82-99%) and large (1-18%) lymphocytes. In all stages of the estrous cycle, IEL occurred with a frequency of 68-87% in the basal region, 8-20% in the middle region and 4-12% in the apical region of the luminal epithelium width.
分析了未孕大鼠子宫腔上皮和腺上皮中上皮内淋巴细胞（IEL）的数量，观察阶段包括动情后期、动情前期和动情期，以及未孕大鼠妊娠第5、7和9天。IEL数量的计算是相对于上皮细胞数量或上皮切片长度而言的。结果发现，在动情后期，平均每100个腔上皮细胞中有3.7个IEL，或每1毫米上皮切片中有6.7个IEL；而在动情前期，这一数量分别降至0.9个和1.2个IEL。在妊娠第5天（着床前），每100个腔上皮细胞中的IEL数量进一步降至0.45个，或每1毫米上皮中有0.9个。在妊娠第7天和第9天，着床部位的IEL数量进一步减少，而在非着床部位，其数量保持在妊娠第5天计算的水平。子宫IEL群体由小淋巴细胞（82 - 99%）和大淋巴细胞（1 - 18%）组成。在发情周期的所有阶段，IEL在腔上皮宽度的基部区域出现频率为68 - 87%，在中部区域为8 - 20%，在顶端区域为4 - 12%。
