Lee C S, Meeusen E, Gogolin-Ewens K, Brandon M R
Centre for Animal Biotechnology, School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia.
Am J Reprod Immunol. 1992 Sep;28(2):90-6. doi: 10.1111/j.1600-0897.1992.tb00766.x.
Previous studies have revealed the presence of a unique population of CD45R+ granulated cells in the sheep uterine epithelium. In the present study, dramatic changes in this cell population and in the nongranulated lymphocytes in the uterine and endometrial glandular epithelium of non-cycling, cycling, pregnant, and postparturient sheep are described. In noncycling and cycling sheep, the granules in the granulated intraepithelial cells were small. From days 55 to 134 of pregnancy, the granules in these cells were large, and there was a significant increase (P < 0.01) in the proportion of this cell population in the uterine epithelium but not in the endometrial glandular epithelium located in the deeper region of the stroma. The number of these cells declined dramatically (P < 0.01) from 2 to 15 days after parturition. Both the tissue distribution and the time of activation of these cells suggests they are different from the granulated lymphocytes described in placentae of mice and man.
It is concluded that this unique population of granulated cells is derived from lymphocytes, and that these cells become metabolically active from mid- to late-pregnancy and may play a physiological role during pregnancy or birth. In contrast, the number of nongranulated intraepithelial lymphocytes were suppressed throughout pregnancy and they probably do not play a role in pregnancy.
先前的研究已揭示绵羊子宫上皮中存在一群独特的CD45R+颗粒细胞。在本研究中，描述了非周期性、周期性、怀孕和产后绵羊子宫及子宫内膜腺上皮中该细胞群以及非颗粒淋巴细胞的显著变化。在非周期性和周期性绵羊中，颗粒上皮内细胞中的颗粒较小。从怀孕第55天到134天，这些细胞中的颗粒变大，子宫上皮中该细胞群的比例显著增加（P < 0.01），但位于基质较深层的子宫内膜腺上皮中则没有。产后2至15天，这些细胞的数量急剧下降（P < 0.01）。这些细胞的组织分布和激活时间表明它们与小鼠和人类胎盘描述的颗粒淋巴细胞不同。
得出的结论是，这群独特的颗粒细胞源自淋巴细胞，并且这些细胞在妊娠中期至晚期变得代谢活跃，可能在妊娠或分娩期间发挥生理作用。相比之下，整个妊娠期非颗粒上皮内淋巴细胞数量受到抑制，它们可能在妊娠中不发挥作用。
