参与葡萄糖代谢的基因的成对相关性：癌症的潜在诊断标志物？
Pairwise correlation of genes involved in glucose metabolism: a potential diagnostic marker of cancer?
作者信息
Sakharkar Meena Kishore, Rajamanickam Karthic, Ji Shaoping, Dhillon Sarinder Kaur, Yang Jian
机构信息
Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Henan Provincial Engineering Centre for Tumor Molecular Medicine, Institute of Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng, Henan Province 474004, P.R. of China.
出版信息
Genes Cancer. 2021 Jun 17;12:69-76. doi: 10.18632/genesandcancer.216. eCollection 2021.
Cancer is a highly malignant disease, killing approximately 10 million people worldwide in 2020. Cancer patient survival substantially relies on early diagnosis. In this study, we evaluated whether genes involved in glucose metabolism could be used as potential diagnostic markers for cancer. In total, 127 genes were examined for their gene expression levels and pairwise gene correlations. Genes and were differentially expressed in most of the 12 types of cancer and five pairs of genes exhibited consistent correlation changes (from strong correlations in normal controls to weak correlations in cancer patients) across all types of cancer. Thus, the two differentially expressed genes and five gene pairs could be potential diagnostic markers for cancer. Further preclinical and clinical studies are warranted to prove whether these genes and/or gene pairs would indeed aid in early diagnosis of cancer.
癌症是一种高度恶性的疾病，2020年在全球导致约1000万人死亡。癌症患者的生存很大程度上依赖于早期诊断。在本研究中，我们评估了参与葡萄糖代谢的基因是否可作为癌症的潜在诊断标志物。总共检测了127个基因的基因表达水平和基因对之间的相关性。基因 和 在12种癌症中的大多数中存在差异表达，并且五对基因在所有类型的癌症中均表现出一致的相关性变化（从正常对照中的强相关性到癌症患者中的弱相关性）。因此，这两个差异表达基因和五对基因对可能是癌症的潜在诊断标志物。有必要进行进一步的临床前和临床研究，以证明这些基因和/或基因对是否确实有助于癌症的早期诊断。
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