Liu Shunjie, Li Yuanyuan, Kwok Ryan T K, Lam Jacky W Y, Tang Ben Zhong
Department of Chemistry, The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study, Department of Chemical and Biological Engineering, Division of Life Science, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China
Center for Aggregation-Induced Emission, SCUT-HKUST Joint Research Institute, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology Guangzhou 510640 China.
Chem Sci. 2020 Jun 12;12(10):3427-3436. doi: 10.1039/d0sc02911d.
Aggregation-induced emission (AIE) is a cutting-edge fluorescence technology, giving highly-efficient solid-state photoluminescence. Particularly, AIE luminogens (AIEgens) with emission in the range of second near-infrared window (NIR-II, 1000-1700 nm) have displayed salient advantages for biomedical imaging and therapy. However, the molecular design strategy and underlying mechanism for regulating the balance between fluorescence (radiative pathway) and photothermal effect (non-radiative pathway) in these narrow bandgap materials remain obscure. In this review, we outline the latest achievements in the molecular guidelines and photophysical process control for developing highly efficient NIR-II emitters or photothermal agents with aggregation-induced emission (AIE) attributes. We provide insights to optimize fluorescence efficiency by regulating multi-hierarchical structures from single molecules (flexibilization) to molecular aggregates (rigidification). We also discuss the crucial role of intramolecular motions in molecular aggregates for balancing the functions of fluorescence imaging and photothermal therapy. The superiority of the NIR-II region is demonstrated by fluorescence/photoacoustic imaging of blood vessels and the brain as well as photothermal ablation of the tumor. Finally, a summary of the challenges and perspectives of NIR-II AIEgens for theranostics is given.
聚集诱导发光（AIE）是一种前沿的荧光技术，可产生高效的固态光致发光。特别是，发射波长在第二近红外窗口（NIR-II，1000 - 1700 nm）范围内的聚集诱导发光分子（AIEgens）在生物医学成像和治疗方面展现出显著优势。然而，这些窄带隙材料中调节荧光（辐射途径）和光热效应（非辐射途径）之间平衡的分子设计策略和潜在机制仍不明确。在这篇综述中，我们概述了在开发具有聚集诱导发光（AIE）特性的高效NIR-II发射体或光热剂的分子指导原则和光物理过程控制方面的最新成果。我们提供了通过从单分子（柔性化）到分子聚集体（刚性化）调节多层次结构来优化荧光效率的见解。我们还讨论了分子聚集体中分子内运动在平衡荧光成像和光热治疗功能方面的关键作用。通过血管和大脑的荧光/光声成像以及肿瘤的光热消融证明了NIR-II区域的优越性。最后，给出了NIR-II AIEgens在诊疗方面的挑战和前景总结。
Zotero 插件